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  4. Rat Interleukin 17,IL-17 ELISA KIT

Rat Interleukin 17,IL-17 ELISA KIT

  • 中文名稱：
    大鼠白介素17(IL-17)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E07451r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠白介素17(IL-17)酶聯(lián)免疫試劑盒（CSB-E07451r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL17A含量。IL17A是一種細(xì)胞因子。其作為靶點(diǎn)，在自身免疫性疾病如銀屑病、強(qiáng)直性脊柱炎等背景下備受關(guān)注。研究機(jī)制主要是它能介導(dǎo)炎癥反應(yīng)，促進(jìn)促炎細(xì)胞因子釋放，影響免疫細(xì)胞功能，通過阻斷IL17A有望治療這些與炎癥相關(guān)的疾病。試劑盒檢測范圍為93.75 pg/mL-6000 pg/mL，該產(chǎn)品廣泛應(yīng)用于炎癥相關(guān)疾病動物模型研究（如關(guān)節(jié)炎、腸炎等）、免疫調(diào)控機(jī)制探索以及藥物干預(yù)效果評價等領(lǐng)域，例如通過檢測組織勻漿中的IL - 17水平分析局部炎癥狀態(tài)，或利用血漿樣本評估系統(tǒng)性免疫應(yīng)答。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il17a ELISA Kit; Ctla8 ELISA Kit; Il17Interleukin-17A ELISA Kit; IL-17 ELISA Kit; IL-17A ELISA Kit; Cytotoxic T-lymphocyte-associated antigen 8 ELISA Kit; CTLA-8 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    93.75 pg/mL-6000 pg/mL
  • 靈敏度：
    23.43 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-17 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 87  
    Range % 80-95  
    1:2 Average % 85  
    Range % 80-95  
    1:4 Average % 90  
    Range % 86-100  
    1:8 Average % 92  
    Range % 86-97  
  • 回收率：
    The recovery of rat IL-17 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 90 85-98  
    EDTA plasma (n=4) 93 88-101  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    6000 1.865 1.802 1.834 1.739  
    3000 1.418 1.376 1.397 1.302  
    1500 1.036 1.004 1.020 0.925  
    750 0.624 0.589 0.607 0.512  
    375 0.379 0.364 0.372 0.277  
    187.5 0.211 0.209 0.210 0.115  
    93.75 0.132 0.122 0.127 0.032  
    0 0.099 0.091 0.095 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    IL17A是一種介導(dǎo)炎癥反應(yīng)的細(xì)胞因子，在自身免疫疾病和腫瘤等多種疾病中發(fā)揮重要作用。最新的研究表明，IL17A在肺癌中的作用十分復(fù)雜，可能具有促進(jìn)或抑制腫瘤發(fā)展的雙重作用。此外，研究人員還發(fā)現(xiàn)，通過靶向IL17A和其受體可以增強(qiáng)腫瘤免疫應(yīng)答和抑制腫瘤的生長和轉(zhuǎn)移，為腫瘤治療提供了新的方向。
  • 功能：
    Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 數(shù)據(jù)庫鏈接：