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  4. Rat Interleukin 2,IL-2 ELISA kit

Rat Interleukin 2,IL-2 ELISA kit

  • 中文名稱：
    大鼠白介素2(IL-2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04628r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠白介素2(IL-2)酶聯(lián)免疫試劑盒（CSB-E04628r）為雙抗夾心法ELISA試劑盒，定量檢測血清、尿液、組織勻漿樣本中的IL2含量。IL-2即白細(xì)胞介素-2，是一種免疫細(xì)胞因子。它由T細(xì)胞產(chǎn)生，在免疫系統(tǒng)中扮演重要角色，能促進(jìn)T細(xì)胞、B細(xì)胞增殖分化，增強(qiáng)NK細(xì)胞活性等。通過與受體結(jié)合，激活下游信號通路來調(diào)節(jié)免疫反應(yīng)，有望用于腫瘤、感染等疾病治療。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，靈敏度為1.56 pg/mL。該產(chǎn)品適用于科研實驗中評估大鼠免疫激活狀態(tài)，例如研究炎癥性疾病模型（如自身免疫疾病或感染模型）中細(xì)胞因子網(wǎng)絡(luò)的變化規(guī)律，亦可應(yīng)用于藥物研發(fā)中免疫調(diào)節(jié)劑的效果評價，或通過分析組織勻漿樣本探究局部免疫微環(huán)境的IL - 2分泌特征。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il2 ELISA kit; Il-2Interleukin-2 ELISA kit; IL-2 ELISA kit; T-cell growth factor ELISA kit; TCGF ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, urine, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %92
    Range %87-98
    1:2Average %98
    Range %91-104
    1:4Average %89
    Range %84-99
    1:8Average %96
    Range %92-100
  • 回收率：
    The recovery of rat IL-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9085-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.489 2.478 2.484 2.289
    2001.954 1.896 1.925 1.730
    1001.292 1.273 1.283 1.088
    500.797 0.768 0.783 0.588
    250.503 0.489 0.496 0.301
    12.50.364 0.356 0.360 0.165
    6.250.276 0.258 0.267 0.072
    00.198 0.192 0.195 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價

靶點詳情

  • 功能：
    Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that C-rel binding on the interleukin-2 (IL-2) promoter region declined in the aged CD4+T cells. PMID: 24853588
    2. our findings indicate a generic and robust stress-induced reduction in plasma IL-12 PMID: 22659252
    3. Effects of systemic IL-2 on neurotransmission in several cortical areas is measured by in-vivo microdialysis; IL-2 has dose-dependent effects on depressive-related behavior after delayed but not acute testing, but no effects on anxiety-like behavior. PMID: 21726905
    4. The purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD in muscle and adipose tissue. PMID: 21668966
    5. IL-2 neuroprotective action upon retinal ganglion cells in vitro is mediated by Janus kinase and extracellular signal-regulated kinase 1/2 activation. PMID: 21262542
    6. In a living cell imaging study, treatment with IL-2 at different concentrations during development of cultured hippocampal neurons induces major changes in dendritic branches, filopodia mobility, and spine density. PMID: 20225203
    7. The pIL-2-shRNA interference plasmid could decrease proinflammatory cytokine production of T lymphocytes and protect hepatocytes from apoptosis in allografts. PMID: 19589546
    8. IL-2 may participate in the immune rejection in allogeneic liver transplantation. PMID: 18471351
    9. effects of IL-2 on contraction and the [Ca2+]i transient of ventricular myocytes are mediated via the cardiac kappa opioid receptor. PMID: 11907831
    10. IL-1alpha and IL-2 produce an increase of glucose metabolism in uteri isolated from underfed rats PMID: 12878449
    11. Analysis of murine CD28 mutants reveals a correlation between translocation to lipid rafts and costimulation of IL-2 production. PMID: 15280538
    12. These results provide new evidence indicating that cytokine mRNA in the brain can be related to elevated plus-maze behavior and that this relationship is site (prefrontal cortex, striatum)- and cytokine mRNA-specific (IL-2). PMID: 15950774
    13. hypothalamic IL2 is decreased after intranasal administration of Epithalon PMID: 17152351
    14. stress-induced increase in serum IL-6 level and decrease in IL-2 level PMID: 17433709
    15. Cell activation in hypothalamus correlated with decreases in the quantity of IL-2-positive cells. PMID: 18264770
    16. Data suggest that estradiol effects on T cell IFN-gamma abd IL-2 production afer trauma-hemorrhage are mediated via non-genomic pathway, and which is in turn mediated via ERK, p38, and JNK pathways. PMID: 18343154
    17. Data show that inescapable and escapable stressors have different effects on behavior in the modified active avoidance test and on IL-2 levels in brain areas that are known to be involved in emotional processes. PMID: 18628674
    18. CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses. PMID: 18827184

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-2 family
  • 數(shù)據(jù)庫鏈接：