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  4. Rat Interleukin 6 receptor,IL-6R ELISA Kit

Rat Interleukin 6 receptor,IL-6R ELISA Kit

  • 中文名稱：
    大鼠白介素6受體(IL-6R)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E11876r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠白介素6受體(IL-6R)酶聯(lián)免疫試劑盒（CSB-E11876r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IL6R含量。IL6R即白細(xì)胞介素 6 受體，在人體免疫調(diào)節(jié)等生理過程中起關(guān)鍵作用。其異常與多種炎癥性疾病、自身免疫病及腫瘤發(fā)生發(fā)展相關(guān)。研究通過阻斷 IL6R 信號(hào)傳導(dǎo)，抑制相關(guān)細(xì)胞因子釋放，為相關(guān)疾病治療提供新思路。試劑盒檢測(cè)范圍為0.625 ng/mL-40 ng/mL，該產(chǎn)品適用于基礎(chǔ)科研中炎癥性疾病模型評(píng)估、免疫調(diào)控機(jī)制研究或藥物干預(yù)效果分析等領(lǐng)域，為科研工作者探索IL - 6/IL - 6R信號(hào)通路提供高效工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il6r; Il6ra; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; CD antigen CD126
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-6R in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %99
    Range %91-103
    1:2Average %100
    Range %95-104
    1:4Average %89
    Range %83-92
    1:8Average %93
    Range %84-97
  • 回收率：
    The recovery of rat IL-6R spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10192-105
    EDTA plasma (n=4)9991-103
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    402.492 2.437 2.465 2.289
    202.077 1.981 2.029 1.853
    101.289 1.300 1.295 1.119
    50.799 0.787 0.793 0.617
    2.50.470 0.461 0.466 0.290
    1.250.394 0.388 0.391 0.215
    0.6250.260 0.252 0.256 0.080
    00.178 0.174 0.176
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory. Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells.; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the proinflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis.
  • 亞細(xì)胞定位：
    [Interleukin-6 receptor subunit alpha]: Cell membrane; Single-pass type I membrane protein.; [Soluble interleukin-6 receptor subunit alpha]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 3 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：