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  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit

Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit

  • 中文名稱：
    大鼠巨噬細(xì)胞集落刺激因子1受體(CSF1R)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL006044RA
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠巨噬細(xì)胞集落刺激因子1受體(CSF1R)酶聯(lián)免疫試劑盒（CSB-EL006044RA）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CSF1R含量。CSF1R，即集落刺激因子1受體，是一種酪氨酸激酶跨膜受體，屬于生長(zhǎng)因子CSF-1/血小板衍生生長(zhǎng)因子（PDGF）受體家族。它參與調(diào)節(jié)單核吞噬細(xì)胞（如巨噬細(xì)胞、單核細(xì)胞）的存活、增殖、分化、招募和功能。CSF1R的研究機(jī)制涉及其在腫瘤微環(huán)境中的作用，以及與IL-34和CSF-1的相互作用，對(duì)腫瘤免疫療效有重要影響。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，適用于體外研究巨噬細(xì)胞功能調(diào)控、免疫應(yīng)答機(jī)制探索及相關(guān)疾病模型的分子機(jī)制分析。該產(chǎn)品嚴(yán)格進(jìn)行批次間質(zhì)控，提供詳細(xì)的實(shí)驗(yàn)方案和標(biāo)準(zhǔn)曲線參考，為科研人員在神經(jīng)退行性疾病、腫瘤免疫或組織修復(fù)等領(lǐng)域的分子機(jī)制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    Csf1r ELISA kit; Csfmr ELISA kit; FmsMacrophage colony-stimulating factor 1 receptor ELISA kit; CSF-1 receptor ELISA kit; CSF-1-R ELISA kit; CSF-1R ELISA kit; M-CSF-R ELISA kit; EC 2.7.10.1 ELISA kit; Proto-oncogene c-Fms ELISA kit; CD antigen CD115 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat CSF1R in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 89
    Range % 86-92
    1:2 Average % 108
    Range % 104-112
    1:4 Average % 89
    Range % 85-94
    1:8 Average % 107
    Range % 103-110
  • 回收率：
    The recovery of rat CSF1R spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 84 80-88
    EDTA plasma (n=4) 107 103-110
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.466 2.438 2.452 2.349
    10 1.867 1.902 1.885 1.782
    5 1.239 1.268 1.254 1.151
    2.5 0.751 0.738 0.745 0.642
    1.25 0.445 0.451 0.448 0.345
    0.625 0.287 0.269 0.278 0.175
    0.312 0.207 0.210 0.209 0.106
    0 0.102 0.104 0.103 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages.
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    UniGene: Rn.72599