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Rat Mucin-4(MUC4) ELISA kit

  • 中文名稱:
    大鼠粘蛋白-4(MUC4)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-EL015227RA
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠粘蛋白-4(MUC4)酶聯(lián)免疫試劑盒(CSB-EL015227RA)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的MUC4含量。MUC4是一種跨膜黏蛋白,在多種惡性腫瘤中高表達(dá)。其背景上,與腫瘤的發(fā)生、發(fā)展及轉(zhuǎn)移密切相關(guān)。研究機(jī)制方面,它能參與細(xì)胞信號(hào)傳導(dǎo),調(diào)節(jié)細(xì)胞黏附、增殖和凋亡等過程,還可影響腫瘤微環(huán)境,成為腫瘤治療有潛力的靶點(diǎn)。試劑盒檢測(cè)范圍為0.78 ng/mL-50 ng/mL,適用于科研領(lǐng)域中對(duì)呼吸道、消化道等黏膜相關(guān)疾病模型、腫瘤微環(huán)境研究或藥物干預(yù)實(shí)驗(yàn)中MUC4蛋白動(dòng)態(tài)變化的定量分析,為探索黏膜屏障功能調(diào)節(jié)機(jī)制及生物標(biāo)志物研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Muc4; Smc; Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Pre-sialomucin complex; pSMC; Sialomucin complex; Testis mucin
  • 縮寫:
    MUC4
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍:
    0.78 ng/mL-50 ng/mL
  • 靈敏度:
    0.195 ng/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Signal Transduction
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
  • 亞細(xì)胞定位:
    [Mucin-4 beta chain]: Cell membrane; Multi-pass membrane protein.; [Mucin-4 alpha chain]: Secreted.
  • 組織特異性:
    Expression is developmentally regulated in the mammary gland, dramatically increases in the lactating gland compared with the virgin mammary gland, while decreasing again during mammary gland involution. Expressed in 13762 ascites cells. Overexpressed in