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Rat Retinol binding protein 4,RBP-4 ELISA Kit

  • 中文名稱:
    大鼠視黃醇結(jié)合蛋白4(RBP-4)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E09424r
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3900/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠視黃醇結(jié)合蛋白4(RBP-4)酶聯(lián)免疫試劑盒(CSB-E09424r)為競(jìng)爭(zhēng)法ELISA試劑盒,定量檢測(cè)樣本中的RBP4含量。RBP4,全稱視黃醇結(jié)合蛋白4,是一種在血漿中運(yùn)輸視黃醇的重要蛋白,由肝細(xì)胞合成,并在多種體液中分布。它在視黃醇的運(yùn)輸和分布過程中發(fā)揮關(guān)鍵作用,與TTR和STRA6等蛋白相互作用,參與調(diào)節(jié)視黃醇的細(xì)胞膜運(yùn)輸和防止腎小球?yàn)V過損失。RBP4的研究涉及其在代謝、心血管疾病和胰島素抵抗等病理過程中的作用機(jī)制。適用于代謝疾病機(jī)制研究、營養(yǎng)學(xué)實(shí)驗(yàn)或藥物干預(yù)模型中RBP - 4動(dòng)態(tài)變化的分析,為肥胖、糖尿病等科研領(lǐng)域提供可靠的數(shù)據(jù)支持,僅限科學(xué)研究使用。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Rbp4 ELISA Kit; Retinol-binding protein 4 ELISA Kit; Plasma retinol-binding protein ELISA Kit; PRBP ELISA Kit; RBP ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
  • 檢測(cè)范圍:
  • 靈敏度:
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Signal Transduction
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Competitive
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展:
    RBP4是一種在維生素A代謝中起關(guān)鍵作用的蛋白質(zhì),但它也與一些代謝性疾病如肥胖、糖尿病和代謝綜合征等有關(guān)。一些最新的研究表明,RBP4可能作為這些疾病的潛在生物標(biāo)志物和治療靶點(diǎn),有望為相關(guān)疾病的治療提供新的思路和策略。
  • 功能:
    Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
  • 基因功能參考文獻(xiàn):
    1. RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
    2. plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
    3. Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
    4. Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
    5. Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
    6. RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
    7. Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839

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  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Calycin superfamily, Lipocalin family
  • 組織特異性:
    Detected in blood plasma (at protein level).
  • 數(shù)據(jù)庫鏈接: