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Rat Soluble Lectin-like Oxidized Low Density Lipoprotein Receptor-1(sLOX-1)ELISA Kit

  • 中文名稱:
    大鼠可溶性凝集素樣氧化低密度脂蛋白受體1(sLOX-1)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E15845r
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠可溶性凝集素樣氧化低密度脂蛋白受體1(sLOX-1)酶聯(lián)免疫試劑盒(CSB-E15845r)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的OLR1含量。OLR1是一種重要靶點(diǎn)。它在動(dòng)脈粥樣硬化、炎癥等病理過程中扮演關(guān)鍵角色。研究機(jī)制方面,主要聚焦于其與氧化低密度脂蛋白的結(jié)合,引發(fā)細(xì)胞內(nèi)一系列信號(hào)傳導(dǎo),影響細(xì)胞功能,目前圍繞其開發(fā)干預(yù)措施以治療相關(guān)疾病的研究不斷推進(jìn)。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL,適用于心血管疾病模型研究、代謝綜合征機(jī)制探索及藥物干預(yù)效果評(píng)估等科研場景本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Olr1; Lox1; Oldlr1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.156 ng/mL-10 ng/mL
  • 靈敏度:
    0.039 ng/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of rat sLOX-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %90
    Range %85-94
    1:2Average %92
    Range %88-99
    1:4Average %88
    Range %84-92
    1:8Average %95
    Range %90-100
  • 回收率:
    The recovery of rat sLOX-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8580-90
    EDTA plasma (n=4)9490-98
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1OD2AverageCorrected
    102.375 2.227 2.301 2.190
    51.816 1.902 1.859 1.748
    2.51.240 1.208 1.224 1.113
    1.250.725 0.785 0.755 0.644
    0.6250.421 0.439 0.430 0.319
    0.3120.263 0.284 0.274 0.163
    0.1560.218 0.221 0.220 0.109
    00.109 0.112 0.111
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 基因功能參考文獻(xiàn):
    1. an important role of LOX-1 in the maintenance of PASMCs phenotype. PMID: 29069578
    2. data support an important role for STBEVs in impairment of vascular function via activation of LOX-1 and reduced nitric oxide mediated vasodilation. Moreover, we postulate that the LOX-1 pathway could be a potential therapeutic target in pathologies associated with vascular dysfunction during pregnancy PMID: 28672042
    3. Negative feedback regulation between let-7g and LOX-1 mediated hypoxia-induced proliferation of in pulmonary artery smooth muscle cells (PASMCs). PMID: 28108289
    4. LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats PMID: 28259654
    5. Losartan attenuated lung injury by suppressing LOX-1 expression to alleviate inflammation and cell apoptosis. PMID: 26884836
    6. Swimming exercise reduced heart expression of LOX-1 receptor and free radical production in experimental diabetes. PMID: 26432573
    7. OLR1 is a novel molecular link between the proliferative and inflammatory responses of vascular smooth muscle cells. PMID: 26305474
    8. data indicated that olmesartan may attenuate the impairment of endothelial cell via down-regulation of the increased LOX-1 expression induced by ox-LDL. PMID: 22408405
    9. EETs exert beneficial effects on ox-LDL-induced inflammation primarily through the inhibition of LOX-1 receptor upregulation, MAPK phosphorylation, and NF-kappaB activation and through the upregulation of CYP2J4 expression. PMID: 24486707
    10. LOX-1 is a promising therapeutic target in neonatal HIE, and the inhibition of LOX-1 may become a novel treatment for babies who have experienced asphyxia. PMID: 24731447
    11. results indicate that LOX-1 is essential in microglia for promoting an inflammatory response in the presence of soluble neuronal-injury signals such as extracellular HSP60, thereby linking neuroinflammation and neurotoxicity PMID: 22847064
    12. LOX-1 activation by oxLDL and subsequent peroxynitrite generation as a novel mechanism by which disruption of the BBB occurs in EPE. PMID: 23230281
    13. These findings indicated that LOX-1 expression was up-regulated in the cortex of SHR and its expression has implication in neuronal apoptosis. PMID: 22885180
    14. In a rat model of preeclampsia, there is dramatic increase in expression levels of both LOX-1 receptor and endothelial NO synthase enzyme, along with increased superoxide production and modestly decreased endothelial function. PMID: 22392901
    15. Inhibition of rat LOX-1 receptor reduces leukocyte adhesion in experimental endotoxemia. PMID: 21143965
    16. Data show that a high fat diet elevates LOX-1 protein and mRNA expression in aorta, and that sleeve gastrectomy decreases plasma LDL levels, and downregulates LOX-1 protein and mRNA expression. PMID: 21990956
    17. LOX-1 appears to be involved in CRP-induced complement activation, and thus may serve to locate the site of CRP-induced complement activation and inflammation. PMID: 21821723
    18. enhanced expression and activation of LOX-1 mediated the enhancement of vascular permeability, which contributed to the vascular lipid accumulation under hypertensive states PMID: 20216085
    19. expression pattern of LOX1-R in brain microvessels endothelial cells and its modulation by astrocytes PMID: 12095612
    20. findings indicate that myocardial ischemia-reperfusion upregulates LOX-1 expression, which through p38 MAPK activation increases the expression of MMP-1 and adhesion molecules PMID: 12384456
    21. LOX-1 may have a role in the pathogenesis of osteoarthritis, inducing chondrocyte death through PI3 kinase/Akt pathway. PMID: 12435393
    22. LOX-1 is an adhesion molecule involved in leukocyte recruitment and may represent an attractive target for modulation of endotoxin-induced inflammation PMID: 12538855
    23. enhanced renal expression of olr1 might play some roles in the progression of chronic renal failure in rats. PMID: 12661921
    24. LOX-1 up-regulation is redox-sensitive PMID: 16055083
    25. the bradykinin-eNOS and oxidative stress-LOX-1 pathway have roles in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibition PMID: 16214149
    26. LOX-1 activation driven by lipid oxidants in the preurine fluid is critical in inflammatory changes PMID: 18322020
    27. Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression at transcriptional and translational level in brain astrocytes, which are mediated through mitogen-activated protein kinase signaling pathways leading to AP-1 activation. PMID: 18661553

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  • 亞細(xì)胞定位:
    Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted.
  • 組織特異性:
    Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.
  • 數(shù)據(jù)庫鏈接: