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  4. Rat Synaptophysin (Syp)ELISA kit

Rat Synaptophysin (Syp)ELISA kit

  • 中文名稱：
    大鼠突觸體素/突觸素(Syp/SYN)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E13827r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠突觸體素/突觸素(Syp/SYN)酶聯(lián)免疫試劑盒（CSB-E13827r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)組織勻漿樣本中的SYP含量。突觸體素（Synaptophysin，SYP）是一種在神經(jīng)元中廣泛表達(dá)的膜蛋白，參與突觸小泡的形成和胞吐作用，對(duì)突觸功能和神經(jīng)遞質(zhì)釋放至關(guān)重要。其研究機(jī)制涉及突觸小泡的生成、神經(jīng)遞質(zhì)的裝載和釋放，以及神經(jīng)可塑性和神經(jīng)退行性疾病的發(fā)生。試劑盒檢測(cè)范圍為0.625 ng/mL-40 ng/mL，適用于定量分析組織勻漿樣本中Syp/SYN的蛋白表達(dá)水平；為神經(jīng)環(huán)路機(jī)制、阿爾茨海默病或帕金森病動(dòng)物模型研究提供可靠工具；支持神經(jīng)生物學(xué)、藥理學(xué)等領(lǐng)域的基礎(chǔ)研究，助力探索突觸功能異常相關(guān)疾病的分子機(jī)制；適用于腦組織、脊髓等神經(jīng)系統(tǒng)的勻漿樣本分析本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Syp; Synaptophysin; Major synaptic vesicle protein p38
  • 縮寫：
    SYP
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    tissue homogenates
  • 檢測(cè)范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    402.265 2.252 2.259 2.098
    201.561 1.476 1.519 1.358
    100.945 0.904 0.925 0.764
    50.602 0.579 0.591 0.430
    2.50.423 0.401 0.412 0.251
    1.250.301 0.295 0.298 0.137
    0.6250.238 0.229 0.234 0.073
    00.164 0.157 0.161 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 基因功能參考文獻(xiàn)：
    1. The environmental enrichment protected against the effects of maternal separation as indicated by the lower anxiety levels and the reversal of spatial memory deficits compared to animals housed in standard conditions. These changes were associated with increased synaptophysin expression in the hippocampus. PMID: 29545098
    2. Dexamethasone treatment significantly affects both GAP-43 and synaptophysin protein expression in the hippocampus of aged rats. PMID: 28801169
    3. Synaptophysin cerebellar cortex expression was significantly reduced in newborn animals from diabetic mothers. PMID: 27389246
    4. showed a significant down-regulation in mRNA expression of synaptophysin in the offspring born to diabetic animals PMID: 26794272
    5. Synaptophysin spinal cord levels were higher in balance and coordination trained animals compared with non-trained following sciatic nerve crush. PMID: 26316168
    6. the Nociceptin/orphanin FQ receptor system influences the expression of synaptophysin PMID: 25697061
    7. Results identified interesting differences between thienorphine and morphine in their effects on synaptic structure and synaptophysin expression in the rat NAc. PMID: 24861887
    8. Synaptophysin content was high in all the layers of the cortex, but the most intense reaction was detected in the molecular layer, similarly with the intensity of GFAP reaction PMID: 25282817
    9. data suggest that diabetes increases mRNA translation of synaptophysin in the retina, resulting in an accumulation of mannose rich glycosylated synaptophysin, a transient post-translational state of the protein PMID: 22970294
    10. Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I. PMID: 23103755
    11. The expression of synaptophysin (SYP) and regenerationassociated protein (GAP43) in the injured brain of neural stem cells-transplanted rats was significantly increased. PMID: 21687946
    12. The developmental changes of GluR2 and SYP expression in the rat inferior colliculus may be involved in the development and plasticity of the auditory center. PMID: 20422983
    13. GAP-43 and P38 may be the pathological basis of insular epilepsy and the key molecular mechanism of synaptic plasticity. PMID: 20646586
    14. Our findings implicate decreases in the number of surviving cells and alterations in the levels of caveolin-1 and synaptophysin in the impairments in neural development induced by developmental iodine deficiency and hypothyroidism. PMID: 20025630
    15. stress during pregnancy reduced the expression of synaptophysin; this decrease provides evidence that synaptic integral membrane proteins are involved in altered synaptic plasticity in the adult CNS following stress exposure PMID: 20035832
    16. The expression level of synaptophysin showed dynamic changes following diffuse brain injury as well as during the repair period. PMID: 17330749
    17. Data suggest that synaptophysin I has multiple roles in neurotransmitter release, regulating VAMP2 availability for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex and participating in the late steps of exocytosis PMID: 12181340
    18. Synaptophysin mRNA increased in the barrel cortex contralateral to whisker stimulation, suggesting that synaptophysin is involved in the modulation of synaptic plasticity. PMID: 12363201
    19. We found a kindling-induced increase in synaptophysin in various hippocampal regions and in pyriform cortex, suggesting that activation-induced sprouting extends well beyond the hippocampal mossy fiber system. cortex PMID: 12453493
    20. Synaptophysin and gamma-adaptin occurred in the perinuclear region of hippocampal neurons, suggesting that synaptophysin serves as a docking site for AP-1 during clathrin-dependent vesicle budding and/or kinesin-based transport reactions. PMID: 12498786
    21. synaptophysin targeting to a ubiquitous synaptic vesicle-sized compartment is facilitated by cellugyrin and synaptogyrin PMID: 12928441
    22. Synaptophysin expression was assessed in dentate gyrus prepared from aged (22 months) and young (4 months) rats; marked reduction in synaptophysin expression in synaptosomes of aged compared with young rats was noted PMID: 12965244
    23. Restraint stress decreased SYP in rat hippocampus by 50% and increased microtubule-associated protein 1(MAP1) by 60%. SYP returned to pre-stress levels in three weeks and MAP1 in two weeks. PMID: 15584914
    24. Cognitive impairment and the expression patterns of MAP-2, GAP-43, and synaptophysin were examined in rats with permanent occlusion of bilateral common carotid arteries. PMID: 15964096
    25. The dose-response effects of Aroclor 1254 on the expression of alpha-synuclein, synaptophysin and parkin in rat brains is reported. PMID: 16174552
    26. Following clozapine treatment, synaptophysin expression increases in the very cortical regions in which GLT-1 expression is down-regulated. PMID: 16987241
    27. The mRNA expression level of synaptophysin induced by neuronal activity is related to the regulation of synapse formation or remodeling or both. PMID: 16990974
    28. Synaptophysin expression, which appeared diffusely across the cortex, increased on day 1, 3, and 5 of complex motor skill learning. PMID: 17141532
    29. AMPH administered in the AMPH-paired context increased the density of both Fos and synaptophysin immunoreactivity in the dentate gyrus, cornu ammonis (CA)1, CA3, basolateral amygdala and dorsolateral striatum. PMID: 17970739
    30. reduced synaptophysin protein levels in schizophrenia postmortem brains do not result from perinatal oxygen deprivation PMID: 18626794
    31. Synaptophysin gene is embedded in open chromatin in R28 retinal precursor cells. PMID: 18692536
    32. We found abnormal expression of the synaptic proteins synaptophysin, microtubule-associated protein 2 (MAP2) and cyclin-dependent kinase 5 (CDK5) and of the neurotrophin-3. PMID: 18703118
    33. Results show that nerve growth factor regulates the intracellular distribution of the synaptic vesicle protein synaptophysin in newborn rat trigeminal ganglion neurons in vitro. PMID: 19019428

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  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Synaptophysin/synaptobrevin family
  • 組織特異性：
    Expressed in the brain with expression in the cerebrum and the cerebellum.
  • 數(shù)據(jù)庫(kù)鏈接：