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  4. Rat growth differentiation factor 15(GDF15)ELISA Kit

Rat growth differentiation factor 15(GDF15)ELISA Kit

  • 中文名稱：
    大鼠生長(zhǎng)分化因子15(GDF15)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E16317r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠生長(zhǎng)分化因子15(GDF15)酶聯(lián)免疫試劑盒（CSB-E16317r）為競(jìng)爭(zhēng)法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的GDF15含量。GDF15是一種生長(zhǎng)分化因子。其它在多種組織中表達(dá)，與細(xì)胞生長(zhǎng)、分化等密切相關(guān)。研究機(jī)制上，它能通過與特定受體結(jié)合參與機(jī)體能量代謝、炎癥反應(yīng)等調(diào)節(jié)，在腫瘤、代謝疾病等研究中受關(guān)注。試劑盒檢測(cè)范圍為1.56 pg/mL-100 pg/mL，適用于能量代謝調(diào)控機(jī)制研究、心血管疾病動(dòng)物模型評(píng)估、腫瘤相關(guān)病理分析等科研場(chǎng)景本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名：
    Gdf15 ELISA Kit; SbfGrowth/differentiation factor 15 ELISA Kit; GDF-15 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    1.56 pg/mL-100 pg/mL
  • 靈敏度：
    0.39 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat GDF in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:10Average %92
    Range %87-96
    1:20Average %83
    Range %80-86
    1:40Average %96
    Range %93-99
    1:80Average %102
    Range %99-105
  • 回收率：
    The recovery of rat GDF spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8683-90
    EDTA plasma (n=4)9389-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2Average
    1000.127 0.129 0.128
    500.208 0.220 0.214
    250.334 0.324 0.329
    12.50.472 0.498 0.485
    6.250.713 0.735 0.724
    3.121.162 1.139 1.151
    1.561.542 1.567 1.555
    02.814 2.864 2.839
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (Probable). On hepatocytes, inhibits growth hormone signaling.
  • 基因功能參考文獻(xiàn)：
    1. These findings demonstrate the importance of the AP in the mediation of cancer-dependent anorexia and body weight loss and support a pathological role of MIC-1 as a tumour-derived factor mediating CACS, possibly via an AP-dependent action. PMID: 28025863
    2. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. PMID: 27566082
    3. the time course of the expression of growth differentiation factor15 (GDF15) in rat ischemic myocardium with increasing durations of reperfusion, and to elucidate its physiopathological role in the noreflow phenomenon, is reported. PMID: 26647773
    4. findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells PMID: 26811051
    5. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage PMID: 23986522
    6. Up-regulation of EGR-1 and NAG-1, along with higher reactive oxygen species load may positively regulate the intrinsic pathway of apoptosis for the NSAID mediated chemoprevention of colorectal cancer. PMID: 23435960
    7. Gdf15 expression exhibits increases >10-fold at night in the rat pineal gland, reaching levels that are >15-fold higher than the median in other tissues. PMID: 19103603

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Detected in plasma (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：