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  4. Rat intercellular adhesion molecule 1,ICAM-1 ELISA Kit

Rat intercellular adhesion molecule 1,ICAM-1 ELISA Kit

  • 中文名稱：
    大鼠細(xì)胞間粘附分子1(ICAM-1/CD54)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04576r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠細(xì)胞間粘附分子1(ICAM-1/CD54)酶聯(lián)免疫試劑盒（CSB-E04576r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的ICAM1含量。ICAM1 即細(xì)胞間黏附分子 -1，在炎癥反應(yīng)、免疫調(diào)節(jié)等過程起重要作用。其背景為在多種細(xì)胞表面表達(dá)，受多種細(xì)胞因子調(diào)控。研究機(jī)制主要是介導(dǎo)細(xì)胞間黏附，參與白細(xì)胞遷移等，在炎癥疾病、腫瘤轉(zhuǎn)移等病理過程有重要意義。試劑盒檢測范圍為78.125 pg/mL-5000 pg/mL，靈敏度為24.321 pg/mL。廣泛用于炎癥機(jī)制研究、免疫調(diào)節(jié)實(shí)驗(yàn)、心血管疾病模型構(gòu)建及藥物作用評(píng)估等科研場景，為探索ICAM - 1在病理生理過程中的動(dòng)態(tài)變化提供精準(zhǔn)定量工具，尤其適用于動(dòng)物模型樣本中低濃度ICAM - 1的檢測需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Icam1; Icam-1; Intercellular adhesion molecule 1; ICAM-1; CD antigen CD54
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    78.125 pg/mL-5000 pg/mL
  • 靈敏度：
    24.321 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    ICAM1，全稱為細(xì)胞間黏附分子1（Intercellular Adhesion Molecule 1），是一種參與免疫和炎癥過程的跨膜糖蛋白，在免疫細(xì)胞、血管內(nèi)皮細(xì)胞和其他組織中廣泛表達(dá)。ICAM1通過與其受體LFA-1的結(jié)合，參與了免疫細(xì)胞的黏附和浸潤，并在炎癥反應(yīng)、感染、腫瘤轉(zhuǎn)移等疾病的發(fā)生和發(fā)展中發(fā)揮重要作用。
    ICAM1在過去的研究中已被證實(shí)與多種疾病的發(fā)生和發(fā)展有關(guān)，如炎癥性疾病、自身免疫性疾病、心血管疾病、感染等。目前，ICAM1的研究主要集中在其在疾病發(fā)生、發(fā)展和治療中的作用機(jī)制以及其在藥物篩選和治療中的應(yīng)用等方面。
  • 功能：
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
  • 基因功能參考文獻(xiàn)：
    1. The results suggest that ICAM-1 may play a critical role in bladder inflammation in severe non-bacterial cystitis and may be used as a novel therapeutic target in non-bacterial bladder inflammation such as bladder pain syndrome/interstitial cystitis. PMID: 27782122
    2. Pro-atherogenic effects of aldosterone are mediated by increased ICAM-1 expression, through transcriptional regulation by endothelial MR. PMID: 28089144
    3. Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression. PMID: 27525872
    4. MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway. PMID: 27889748
    5. The results of this study showed that ICAM-1 up regulation in both sexs rats with aneurysmal subarachnoid hemorrhage. PMID: 26923576
    6. intercellular adhesion molecule-1 has a role in the restructuring of the blood-testis barrier during spermatogenesis [review] PMID: 26419651
    7. ICAM-1 induction in vascular endothelium and leukocyte adhesion to vascular endothelium is decreased in NSun2 knock-out rats. PMID: 26838785
    8. ICAM-1 protein expression in the yellow wine (0.5% -1.5%) groups were significantly different. Yellow wine decreases ICAM-1 protein expression. PMID: 26853250
    9. PilE4:ICAM-1 interaction unfolded here may provide a new perspective on molecules involved in the adhesion of extracellular form of Francisella to endothelial cells. PMID: 25769821
    10. findings reveal a novel function of ICAM-1 in osteogenesis and suggest a new molecular target to improve bone regeneration and repair in inflammatory microenvironments. PMID: 24702024
    11. analysis of the role of Txnip, ICAM-1, and NOX2 expression in diabetes-induced endothelial dysfunctions with curcumin PMID: 25054130
    12. No correlation was found between ICAM1 levels and microvascular or macrovascular dysfunction in adjuvant-induced arthritis. PMID: 25708190
    13. Hesperetin-7-O-glucuronide decreased hydrogen peroxide-induced intracellular adhesion molecule-1 and monocyte chemoattractant protein-1 mRNA expression in rat aortic endothelial cells. PMID: 23831969
    14. Exogenously applied caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules. PMID: 24043249
    15. Data illustrate the existence of a unique mechanism in the mammalian testis where ICAM-1 can either positively or negatively regulate blood-testis barrier function. PMID: 22976294
    16. Simvastatin attenuates lung injury induced by ischemia-reperfusion of the hind limb in rats by suppressing the activation of NF-kappaB p65 and subsequent accumulation of neutrophils mediated by ICAM-1. PMID: 21764683
    17. Intercellular adhesion molecule-1 blockade attenuates ischemia/reperfusion injury (IRI) via reduction of leukocyte-endothelial interactions and improvement of capillary perfusion emphasizing its central role during IRI in pancreas transplantation PMID: 22617707
    18. Infection with Japanese encephalitis virus elicits elevated production of intercellular adhesion molecule-1 in brain. PMID: 22845610
    19. Repeated high + Gz exposures could injure cardiovascular endothelium of rat and increase ICAM-1 expression. PMID: 21180061
    20. renal expression increased in spontaneously hypertensive rats with renal damage PMID: 22681549
    21. Melatonin protected lung tissue from acute injury by scavenging free radicals and inhibiting the expression of ICAM-1. PMID: 21158154
    22. Hydrogen sulfide reduced the expressions of NFKB and ICAM1 in pulmonary tissue of rats with acute lung injury. PMID: 22333058
    23. A cholesterol diet plays a role in the expression of ICAM-1 but not in that of VCAM-1 in the rat aorta. The expression of ICAM-1 in the aorta regresses after the withdrawal of a cholesterol-rich diet. PMID: 22351665
    24. The freezing/thawing of vascular endothelial cells can elicit an increase in ICAM-1 expression on the cell surface. PMID: 21162227
    25. Vaspin inhibits TNF-alpha-induced expression of ICAM-1 via preventing the reactive oxygen species generation and subsequent activation of NF-kappaB and PKCtheta;. PMID: 21683791
    26. Data suggest that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. PMID: 21860531
    27. ICAM1 up-regulation at the time of implantation is under the control of progesterone, and is not dependent on cytokine release from the blastocyst or in semen PMID: 21448983
    28. Proteolytic cleavage of the extracellular domain of ICAM-1 and accumulation in kidney glomeruli may play a role in the renal involvement of inflammation. PMID: 21464573
    29. a signaling pathway involving aldose reductase, JNK, IKK, and NF-kappaB is required for ICAM-1 induction in ECs exposed to BFT, and may be involved in the leukocyte-adhesion cascade following infection with ETBF. PMID: 21724992
    30. Aging may upregulate lung MCP-1 and ICAM-1 expressions and enhance LPS-induced increments of MCP-1 and ICAM-1 expressions to exacerbate pulmonary inflammation in rats. PMID: 20335145
    31. Intercellular adhesion molecule 1 (ICAM-1) and E-selectin was down-regulated exclusively in mesenchymal stem cells /mycophenolate mofetil -treated grafts, indicating that MSC together with MMF interfere with endothelial activation PMID: 21194567
    32. Activation of the cholinergic anti-inflammatory pathway can protect the lung against ventilator-induced lung injury by suppressing IL-8 and ICAM-1 expression. PMID: 20663304
    33. in the early phase of acute oral mucosal graft-versus-host disease,the induction of ICAM-1 expression on keratinocytes leads to the migration of CD8+ cells into the epithelium PMID: 21472687
    34. Isoflurane up-regulated the expression of ICAM-1 in LPS-induced rat lung microvascular endothelial cells but sevoflurane and desflurane down-regulated expression. PMID: 20936719
    35. Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. PMID: 21071702
    36. The expression of ICAM-1 and MUC5AC in lung tissue were both significantly higher in allergic rhinitis than that in control group. PMID: 16229173
    37. Salvia significantly reduces the expressions of NF-kappaB and ICAM-1 in ischemia-reperfusion hepatic tissue. PMID: 20979835
    38. during localized inflammatory pain, peripheral sensory and sympathetic nerve fibers augment the expression of vascular endothelial ICAM-1 PMID: 20600813
    39. Baicalin can decrease the contents of TNF-alpha and sICAM-1, and alleviate inflammation in lung tissues of rats infected with Pneumocystis carinii. PMID: 19856505
    40. By up-regulating the expression of ICAM-1 and MMP-9 protein and mRNA in pulmonary vascular wall, cigarette smoke exposure mediated pulmonary vascular inflammation and remodeling. PMID: 20079284
    41. Transferring NF-kappa B p65 antisense oligonucleotides into hepatic stellate cells weakened the expression of ICAM-1 and TGF beta 1 mRNA and the protein induced by TNF alpha. PMID: 18983774
    42. ICAM-1 mRNA analysis may be useful for estimation of early wound age because of its time-related expression after contusion in skin and muscle. PMID: 19241963
    43. Elevated expression of ET-1, iNOS, COX-2, and ICAM-1 occurred in the cortex of middle cerebral artery occlusion (MCAO) model rats. PMID: 20083630
    44. Curcumin can ameliorate cerebral pathological changes in the event of ischemia-reperfusion injury by suppressing the expressions of NF-kappaB and ICAM-1. PMID: 19726347
    45. Leptin induces an inflammatory phenotype in lean Wistar rats that includes increased production of ICAM-1, MCP-1, and IL-6 by hepatocytes PMID: 20150963
    46. The expression of ICAM-1 mRNA peaked at 6 h in skeletal muscle after contusion. PMID: 19697769
    47. retinal expression induced by VEGF PMID: 11839570
    48. These findings suggested that ICAM-1 in endothelial cells may act as a signaling receptor to induce Ets-1 expression in angiogenesis PMID: 11880280
    49. intestinal ischemia and reperfusion injury results in an increase of systemic ICAM-1 expression with marked organ variability PMID: 12095141
    50. study the effect of SOD on the expression of CD11b/CD18 and ICAM-1 after skeletal muscle ischemia / reperfusion injury in rats PMID: 12126535

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, ICAM family
  • 數(shù)據(jù)庫鏈接：

    KEGG: rno:25464

    STRING: 10116.ENSRNOP00000028066

    UniGene: Rn.12