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  • 中文名稱:
    大鼠激肽原(KNG)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E12725r
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3800/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠激肽原(KNG)酶聯(lián)免疫試劑盒(CSB-E12725r)為雙抗夾心法ELISA試劑盒,定量檢測(cè)樣本中的KNG1含量。KNG1 即激肽原 1,是血漿中產(chǎn)生激肽的前體蛋白。它是多種蛋白水解酶的作用底物,在緩激肽生成、凝血啟動(dòng)等生理過(guò)程中發(fā)揮重要作用。對(duì) KNG1 的研究有助于深入了解相關(guān)疾病發(fā)病機(jī)制,并為開(kāi)發(fā)新的治療靶點(diǎn)和藥物提供思路。該產(chǎn)品適用于大鼠生物樣本中KNG蛋白表達(dá)的科研檢測(cè),可支持高血壓病理模型構(gòu)建、炎癥信號(hào)通路解析、藥物干預(yù)效應(yīng)評(píng)估等基礎(chǔ)研究,為探索激肽系統(tǒng)在生理及疾病中的分子機(jī)制提供高效工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    Kng1 ELISA Kit; Kng ELISA Kit; Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain] ELISA Kit
  • 縮寫(xiě):
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類(lèi)型:
  • 檢測(cè)范圍:
  • 靈敏度:
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
  • 基因功能參考文獻(xiàn):
    1. High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury. PMID: 17293494
  • 亞細(xì)胞定位:
    Secreted, extracellular space.
  • 組織特異性:
    Plasma.
  • 數(shù)據(jù)庫(kù)鏈接: