Rat kininogen(KNG) ELISA Kit
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中文名稱:大鼠激肽原(KNG)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-E12725r
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規(guī)格:96T/48T
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價(jià)格:¥3800/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:大鼠激肽原(KNG)酶聯(lián)免疫試劑盒(CSB-E12725r)為雙抗夾心法ELISA試劑盒,定量檢測(cè)樣本中的KNG1含量。KNG1 即激肽原 1,是血漿中產(chǎn)生激肽的前體蛋白。它是多種蛋白水解酶的作用底物,在緩激肽生成、凝血啟動(dòng)等生理過(guò)程中發(fā)揮重要作用。對(duì) KNG1 的研究有助于深入了解相關(guān)疾病發(fā)病機(jī)制,并為開(kāi)發(fā)新的治療靶點(diǎn)和藥物提供思路。該產(chǎn)品適用于大鼠生物樣本中KNG蛋白表達(dá)的科研檢測(cè),可支持高血壓病理模型構(gòu)建、炎癥信號(hào)通路解析、藥物干預(yù)效應(yīng)評(píng)估等基礎(chǔ)研究,為探索激肽系統(tǒng)在生理及疾病中的分子機(jī)制提供高效工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名:Kng1 ELISA Kit; Kng ELISA Kit; Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain] ELISA Kit
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縮寫(xiě):
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類(lèi)型:
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檢測(cè)范圍:
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靈敏度:
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Cardiovascular
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
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基因功能參考文獻(xiàn):
- High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury. PMID: 17293494
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亞細(xì)胞定位:Secreted, extracellular space.
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組織特異性:Plasma.
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數(shù)據(jù)庫(kù)鏈接:
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