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  4. Rat microalbunminuria(MAU/ALB) ELISA kit

Rat microalbunminuria(MAU/ALB) ELISA kit

  • 中文名稱：
    大鼠尿微量白蛋白(MAU/ALB)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E12991r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠尿微量白蛋白(MAU/ALB)酶聯(lián)免疫試劑盒（CSB-E12991r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液樣本中的MAU/ALB含量。MAU/ALB即尿微量白蛋白與尿肌酐比值，是反映早期腎臟損傷的敏感指標(biāo)。其相關(guān)研究主要圍繞通過檢測該比值來評估腎臟微血管病變。因腎臟受損早期可出現(xiàn)微量白蛋白漏出，監(jiān)測MAU/ALB有助于早發(fā)現(xiàn)腎臟疾病，干預(yù)治療以延緩病情進(jìn)展。試劑盒檢測范圍為0.01 μg/mL-40 μg/mL，靈敏度為0.01 μg/mL。微量白蛋白作為評估腎臟功能的重要生物標(biāo)志物，其異常升高常提示早期腎小球濾過功能損傷，廣泛應(yīng)用于糖尿病腎病、高血壓性腎損傷等代謝性疾病動物模型的科研領(lǐng)域。為研究大鼠腎臟疾病進(jìn)展、藥物干預(yù)效果及毒理學(xué)評價提供高效工具，特別適用于實驗動物模型的高通量篩選及縱向研究。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Alb 1 ELISA Kit; alb ELISA Kit; ALBU_RAT ELISA Kit; Albumin ELISA Kit; Serum albumin ELISA Kit
  • 縮寫：
    MAU/ALB
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    0.01 μg/mL-40 μg/mL
  • 靈敏度：
    0.01 μg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat MAU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1000 Average % 93  
    Range % 85-107  
    1:2000 Average % 95  
    Range % 87-104  
    1:4000 Average % 89  
    Range % 84-100  
    1:8000 Average % 90  
    Range % 81-102  
  • 回收率：
    The recovery of rat MAU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 92 88-97  
    EDTA plasma (n=4) 97 90-105  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    μg/ml OD1 OD2 Average Corrected  
    40 2.345 2.412 2.379 2.279  
    10 2.176 2.210 2.193 2.093  
    2.5 1.682 1.657 1.670 1.570  
    0.625 1.237 1.253 1.245 1.145  
    0.156 0.783 0.802 0.793 0.693  
    0.039 0.429 0.436 0.433 0.333  
    0.01 0.272 0.281 0.277 0.177  
    0 0.101 0.098 0.100 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價

靶點詳情

  • 最新研究進(jìn)展：
    MAU和ALB是人體中的兩種蛋白質(zhì)，MAU指尿微量白蛋白，ALB指白蛋白，兩者都是在肝臟中合成的。目前的研究表明，MAU/ALB比值是評估糖尿病腎病患者腎功能的一個重要指標(biāo)，其變化可以提前預(yù)測腎功能損傷的程度。
  • 功能：
    Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
  • 基因功能參考文獻(xiàn)：
    1. Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys. PMID: 28805677
    2. albumin immunoreactivity was newly observed in microglia in the hippocampal CA1 region following 5 min of transient cerebral ischemia. These results indicate that transient ischemia-induced albumin expression in microglia might be associated with ischemia-induced 'delayed neuronal death' in the hippocampal CA1 pyramidal neurons. PMID: 28586018
    3. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn PMID: 26887834
    4. Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 PMID: 26806786
    5. Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation. PMID: 26025362
    6. Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha. PMID: 25888796
    7. Overall, rats with albumin deficiency display enhanced glucose tolerance, insulin secretion and gluconeogenic flux. PMID: 22198013
    8. albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase PMID: 22815976
    9. Data indicate that transcription of Alb is regulated by a complicated system of distant enhancers. PMID: 21858039
    10. This pioneering study determined a higher level of ischemia-modified albumin in a testicular torsion model. PMID: 20452583
    11. Forced expression of PPAR-gamma or C/EBP-alpha in activated pancreatic stellate cells induced albumin expression, thereby reverting cells to the quiescent phenotype. PMID: 19932685
    12. Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control PMID: 11983891
    13. This study suggests that Aroclor 1254 induces elevated albumin serum levels indirectly through induction of liver-enriched transcription factors, which regulate albumin gene expression PMID: 12051991
    14. an accelerated plasma efflux of albumin contributes to hypoalbuminemia only during the early period of sepsis PMID: 12571074
    15. albumin affects glucose metabolism by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism PMID: 12970360
    16. Kinetics of albumin production during rat liver development. PMID: 17879097

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    ALB/AFP/VDB family
  • 組織特異性：
    Plasma.
  • 數(shù)據(jù)庫鏈接：