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  4. Rat transforming growth factor α,TGF-α ELISA Kit

Rat transforming growth factor α,TGF-α ELISA Kit

  • 中文名稱：
    大鼠轉(zhuǎn)化生長(zhǎng)因子α(TGF-α)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E07289r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠轉(zhuǎn)化生長(zhǎng)因子α(TGF-α)酶聯(lián)免疫試劑盒（CSB-E07289r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TGFA含量。TGFA即轉(zhuǎn)化生長(zhǎng)因子α，是表皮生長(zhǎng)因子家族成員。它可與表皮生長(zhǎng)因子受體結(jié)合，激活下游信號(hào)通路，參與細(xì)胞的增殖、分化、遷移等過(guò)程。其異常表達(dá)與腫瘤等疾病的發(fā)生發(fā)展密切相關(guān)，是藥物研發(fā)的潛在靶點(diǎn)。試劑盒檢測(cè)范圍為7.8 pg/ml-500pg/ml，特別適用于動(dòng)物模型中的創(chuàng)傷修復(fù)機(jī)制探究、腫瘤微環(huán)境研究或藥理學(xué)實(shí)驗(yàn)中生物標(biāo)志物動(dòng)態(tài)監(jiān)測(cè)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    7.8 pg/ml-500pg/ml
  • 靈敏度：
    1.95 pg/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 線性度：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
  • 基因功能參考文獻(xiàn)：
    1. 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
    2. Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
    3. results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
    4. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
    5. TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
    6. TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
    7. TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
    8. study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
    9. mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
    10. TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584

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  • 亞細(xì)胞定位：
    [Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:24827

    STRING: 10116.ENSRNOP00000054248

    UniGene: Rn.9952