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  4. ABCB5 Monoclonal Antibody

ABCB5 Monoclonal Antibody

  • 中文名稱：
    ABCB5鼠單克隆抗體
  • 貨號：
    CSB-MA000232
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Hela, 2) 293T, diluted at 1:2000.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ABCB5單克隆抗體（CUSABIO貨號：CSB-MA000232）是針對人源ABCB5靶點(diǎn)開發(fā)的高特異性科研試劑，該靶點(diǎn)作為ATP結(jié)合盒轉(zhuǎn)運(yùn)蛋白家族成員，在腫瘤干細(xì)胞表型維持、藥物外排及組織再生等生物學(xué)過程中發(fā)揮關(guān)鍵調(diào)控作用。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)嚴(yán)格的ELISA和Western Blot（WB）平臺驗(yàn)證，可特異性識別天然構(gòu)象的ABCB5蛋白，適用于腫瘤耐藥機(jī)制研究、干細(xì)胞特性分析及組織特異性表達(dá)檢測等基礎(chǔ)科研領(lǐng)域。該抗體具有高批次穩(wěn)定性，推薦用于石蠟切片/冰凍切片的免疫組化實(shí)驗(yàn)以及細(xì)胞裂解液的蛋白互作研究，為探索ABCB5在黑色素瘤、結(jié)直腸癌等惡性腫瘤中的功能提供可靠工具。在實(shí)驗(yàn)方案設(shè)計(jì)中，建議結(jié)合靶蛋白分子量特征（約130kDa）進(jìn)行WB結(jié)果判讀，同時(shí)可通過多模型交叉驗(yàn)證提升實(shí)驗(yàn)數(shù)據(jù)的可靠性。本產(chǎn)品專注于腫瘤生物學(xué)、分子病理學(xué)等前沿領(lǐng)域研究，為揭示ABCB5介導(dǎo)的多藥耐藥機(jī)制及開發(fā)新型抗癌策略提供優(yōu)質(zhì)抗體支持。
  • Uniprot No.：
  • 基因名：
    ABCB5
  • 別名：
    ABCB 5 antibody; ABCB5 antibody; ABCB5 P-gp antibody; ABCB5_HUMAN antibody; ABCB5alpha antibody; ABCB5beta antibody; ATP binding cassette protein antibody; ATP binding cassette sub family B (MDR/TAP) member 5 antibody; ATP binding cassette sub family B member 5 antibody; ATP-binding cassette sub-family B member 5 antibody; EST422562 antibody; P glycoprotein ABCB5 antibody; P-glycoprotein ABCB5 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    12F4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
  • 基因功能參考文獻(xiàn)：
    1. Interaction analysis demonstrated that the following genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were associated with a prothrombin time >/=12 sec and with Recurrent pregnancy loss (RPL) risk PMID: 29956771
    2. No significant influence of the three newly identified ABCB5 polymorphisms. PMID: 26975227
    3. The ABCB5 activates the NF-kappaB pathway by inhibiting p65 ubiquitination to enhance p65 protein stability. PMID: 28821433
    4. Data indicate that the energy metabolism was virtually unaffected by ATP-binding cassette member B5 (ABCB5) expression. PMID: 27560924
    5. The expression of ZEB1 in tissues is positively relevant to ABCB5 in breast cancer. PMID: 28281973
    6. Findings demonstrated that the expression of ABCB5 was upregulated in ocular surface squamous neoplasia (OSSN) and that elevated expression of ABCB5 may be involved in the pathogenesis of OSSN. PMID: 26843453
    7. Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane. PMID: 26965478
    8. ABCB5 has a role in chemoresistance in Merkel Cell Carcinoma PMID: 26827764
    9. Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons. PMID: 26666373
    10. ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1. PMID: 26321644
    11. This is the first study showing the relationship between miR-340-5p and expression of ABCB5 in melanoma cells PMID: 26554847
    12. c-MYC confers resistance to 5-fluorouracil through regulating ABCB5 expression in human colon cancer cells. PMID: 25689483
    13. ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans. PMID: 25647612
    14. The resistance of CD133(+) melanoma subpopulation is attributed to the enhanced drug efflux mediated by ATP-binding cassette sub-family B member 5 (ABCB5), since the knockdown of ABCB5 was found to sensitize CD133(+) cells to CAPE. PMID: 25449786
    15. In melanoma-initiating cells, ABCB5 controls IL1beta secretion, which serves to maintain slow cycling, chemoresistant cells through an IL1beta/IL8/CXCR1 cytokine signaling circuit. PMID: 24934811
    16. Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression. PMID: 24525737
    17. ABCB5 and MDR1 gene expression correlate with drug resistance in acute leukemia patients. PMID: 24804815
    18. ATP-binding cassette, sub-family B, member 5 (ABCB5) marks limbal stem cells (LSCs) and is required for LSC maintenance, corneal development and repair PMID: 25030174
    19. Our results show that ABCB5 is preferentially expressed in the cytotrophoblast layer of placental villi. PMID: 24300535
    20. Novel associations of the ABCB5 K115E polymorphism with human pigmentation phenotype and melanoma risk are observed. PMID: 23770371
    21. Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Three ABCB5 SNPs, i.e. rs10231520, rs17817117 and rs2301641 (encoding the non-synonymous amino acid change K115E), were associated with decreased clinical melanoma risk. Additionally, the rs2301641 SNP was associated with non-red compared to red human hair color. PMID: 23770371
    22. High ABCB5 expression was significantly associated with tumour progression and recurrence of the tumour. PMID: 22784549
    23. Data show that CD133(+) and ABCB5(+) subpopulations are colocalized in melanomas in perivascular niches that contain CD144 (VE-cadherin)(+) melanoma cells forming vessel-like channels, a phenomenon termed vasculogenic mimicry (VM). PMID: 22865455
    24. The gradual increase in the expression of ABCB5 from benign nevus to in situ to invasive melanoma suggests that it plays a role in melanomagenesis. PMID: 22555176
    25. ABCB5 may be responsible for both the progression and chemotherapeutic refractoriness of advanced acute leukemia. PMID: 22044138
    26. the helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression PMID: 22393060
    27. ABCB5 mediates 5-FU resistance in cultured human colorectal cancer cells and affected tumor growth in xenografts. PMID: 21652540
    28. ABCB5 beta may have evolved to play a specific role in human pigment cells and/or melanoma cells where it is predominantly expressed. PMID: 21298007
    29. Results demonstrate that VEGFR-1 expressed by ABCB5+ malignant melanoma initiating cells functions to induce tumor vasculogenic mimicry and associated production of the pro-proliferative melanoma mitogen laminin, thereby promoting tumor growth. PMID: 21212411
    30. Results identify novel T-cell modulatory functions of ABCB5(+) melanoma subpopulations and suggest specific roles for these malignant melanoma initiating cells in the evasion of antitumor immunity and in cancer immunotherapeutic resistance. PMID: 20068175
    31. Expression of GEP and ABCB5 in liver cancer stem cells is associated with chemoresistance and reduced survival times of patients with hepatocellular carcinoma. PMID: 20682318
    32. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. PMID: 20729912
    33. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
    34. expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas PMID: 15760339
    35. 6-mercaptopurine decreased iNOS expression and increased MRP5 mRNA levels. PMID: 17661346
    36. ABCB5 expression identifies melanoma stem cells and correlates with clinical disease progression in melanoma patients. In vivo targeting of ABCB5+ melanoma stem cells inhibits tumor growth in human to mouse melanoma xenotransplantation models. PMID: 18202660
    37. ABCB5 mediates chemoresistance in stem cell phenotype-expressing human malignant melanoma cells. PMID: 15899824
    38. ABCB5 P-glycoprotein functions include: Regulation of progenitor cell fusion; Regulation of cell membrane potential; Rhodamine-123 transport. PMID: 12960149

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
  • 組織特異性：
    Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expr
  • 數(shù)據(jù)庫鏈接：

    HGNC: 46

    OMIM: 611785

    KEGG: hsa:340273

    STRING: 9606.ENSP00000384881

    UniGene: Hs.404102