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AGBL2 Monoclonal Antibody

  • 中文名稱：
    AGBL2鼠單克隆抗體
  • 貨號：
    CSB-MA732978A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
      All lanes: AGBL2 antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 32 KDa
      Observed band size: 32, 49, 104 KDa
      Exposure time：5min
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號：CSB-MA732978A0m AGBL2單克隆抗體是針對人源AGBL2（ATP/GTP結(jié)合蛋白樣2）靶點研發(fā)的高特異性科研試劑，該蛋白作為胞內(nèi)羧肽酶家族成員，在蛋白質(zhì)翻譯后修飾及細胞信號調(diào)控中發(fā)揮重要作用，其異常表達與多種生理病理過程相關(guān)。本產(chǎn)品經(jīng)Western Blot（WB）和ELISA雙平臺驗證，采用雜交瘤技術(shù)制備，具有明確的IgG亞型鑒定及嚴格的親和純化工藝，確保批次間高一致性。在腫瘤微環(huán)境研究、神經(jīng)退行性疾病機制探索等科研場景中，該抗體可精準識別內(nèi)源性AGBL2蛋白，助力研究者解析其在不同細胞模型或組織樣本中的表達分布規(guī)律及功能調(diào)控網(wǎng)絡(luò)。作為經(jīng)多實驗體系驗證的可靠工具，本品適用于蛋白互作研究、信號通路圖譜構(gòu)建及疾病相關(guān)生物標志物篩選等基礎(chǔ)研究領(lǐng)域，為精準醫(yī)學(xué)研究提供關(guān)鍵技術(shù)支持。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) AGBL2 Monoclonal Antibody antibody
  • Uniprot No.：
  • 基因名：
    AGBL2
  • 別名：
    AGBL 2 antibody; AGBL2 antibody; ATP/GTP binding protein like 2 antibody; ATP/GTP-binding protein-like 2 antibody; Carboxypeptidase 2 cytosolic antibody; CBPC2_HUMAN antibody; CCP2 antibody; Cytosolic carboxypeptidase 2 antibody; FLJ23598 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cytosolic carboxypeptidase 2 protein (10-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal Antibody
  • 抗體亞型：
    IgG2b
  • 純化方式：
    Affinity purification
  • 克隆號：
    1F3C12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
  • 基因功能參考文獻：
    1. Findings suggest that ATP/GTP binding protein like 2 (AGBL2) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC) through modulation on immunity-related GTPase family, M protein (IRGM)-regulated autophagy and aurora kinase A (Aurora A) activity. PMID: 29126912
    2. Suggest role for AGBL2 in cell proliferation and chemotherapy resistance in gastric cancer. PMID: 25916089
    3. High AGBL2 expression is associated with breast cancer. PMID: 24884516
    4. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis. PMID: 21303978
  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Peptidase M14 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26296

    OMIM: 617345

    KEGG: hsa:79841

    STRING: 9606.ENSP00000298861

    UniGene: Hs.147377