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  4. CBX3 Monoclonal Antibody

CBX3 Monoclonal Antibody

  • 中文名稱：
    CBX3鼠單克隆抗體
  • 貨號：
    CSB-MA432292
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP-1γ Mouse mAb diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded Human Placenta Tissue using HP-1γ Mouse mAb diluted at 1:200
    • Western blot analysis of 1) Hela Cell Lysate, 2)3T3 Cell Lysate, 3) PC12 Cell Lysate using HP-1γ Mouse mAb diluted at 1:1000.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號：CSB-MA432292單克隆抗體是針對染色質(zhì)調(diào)控關(guān)鍵因子CBX3開發(fā)的科研專用檢測工具，該蛋白作為異染色質(zhì)蛋白1家族成員，在染色質(zhì)動態(tài)修飾和基因沉默機制中發(fā)揮重要作用。本產(chǎn)品經(jīng)嚴格驗證適用于人、小鼠、大鼠三大物種樣本，可兼容Western Blot、免疫組化（IHC）和ELISA三大檢測平臺，其高特異性和穩(wěn)定性為表觀遺傳學、腫瘤微環(huán)境及干細胞分化研究提供可靠保障。在癌癥發(fā)生機制探索中，該抗體可有效檢測CBX3在DNA損傷修復通路中的定位變化；在細胞重編程研究中，能精準示蹤蛋白在核內(nèi)異染色質(zhì)區(qū)域的動態(tài)分布。通過優(yōu)化抗原表位識別區(qū)域，產(chǎn)品在保留天然構(gòu)象識別能力的同時，顯著降低非特異性結(jié)合風險，是研究染色質(zhì)空間結(jié)構(gòu)調(diào)控、基因印記現(xiàn)象及表觀遺傳修飾網(wǎng)絡(luò)的理想選擇，適用于基因表達譜分析、蛋白質(zhì)互作研究和病理機制解析等前沿領(lǐng)域。
  • Uniprot No.：
  • 基因名：
    CBX3
  • 別名：
    CBX 3 antibody; CBX3 antibody; CBX3_HUMAN antibody; Chromobox homolog 3 (HP1 gamma homolog; Drosophila) antibody; Chromobox homolog 3 antibody; Chromobox protein homolog 3 antibody; GAMMA antibody; HECH antibody; Heterochromatin like protein 1 antibody; Heterochromatin protein 1 homolog gamma antibody; Heterochromatin protein HP1 gamma antibody; HP1 gamma antibody; HP1 gamma homolog antibody; HP1Hs gamma antibody; Modifier 2 protein antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein of HP-1γ
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆號：
    23D7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
  • 基因功能參考文獻：
    1. c-Myc was capable of upregulating HP1gamma by directly binding to the E-box element in the first intron of HP1gamma gene, and the upregulated HP1gamma, in turn, repressed the expression of miR-451a by enhancing H3K9 methylation at the promoter region of miR-451a. PMID: 28967902
    2. CBX3 was overexpressed in pancreatic adenocarcinoma, which was associated with poor prognosis. CDK1 knockdown attenuated the cell cycle transition, proliferation and invasion of CBX3-overexpressing PAAD cells. PMID: 29903985
    3. CBX3 serves as a positive regulator of aerobic glycolysis via suppressing of the FBP1 in pancreatic cancer cells. PMID: 29678579
    4. HP1gamma is present in the nucleus and the cytoplasm interacting with actin, a protein complex that may exert different functions depending on its subcellular localization. PMID: 29208528
    5. CBX3 has a role in promoting tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma PMID: 29462646
    6. The deletion of CBX3 directly enforces the expression of CDK6 and p21. PMID: 28193906
    7. These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin gene expression. PMID: 28154185
    8. these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1gamma, discoveries that have both mechanistic and potentially biomedical relevance. PMID: 26680990
    9. In contrast to HP1alpha, HP1gamma could not recognize H3K9me3 in extended nucleosomes. PMID: 26319017
    10. this study identified miR-30a as a tumor-suppressive microRNA that targets HP1gamma in vitro and in vivo to specifically suppress the growth of colorectal cancer in mouse xenograft models. PMID: 26333808
    11. BARD1 interacts with H3K9me2 through HP1 and plays a critical role in retention of a BRCA1/BARD1 complex at the site of DNA damage. PMID: 25634209
    12. CBX3 and CRABP2 expression was markedly increased in lung cancer tissues PMID: 24751108
    13. our data suggested that HP1gamma plays an important role in promoting non-small cell lung cancer PMID: 24981246
    14. compartmentalized and total HP1gamma protein expression is increased in PCa and that expression correlates with clinical outcomes better than Gleason score. PMID: 23522301
    15. HP1gamma affects the spontaneous differentiation potential of P19 cells, and might play major roles in the decision of cell fates in pluripotent stem cells. PMID: 23313480
    16. Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. PMID: 22870217
    17. Loss of CBX3 results in global RNA processing defect. PMID: 22684280
    18. The Cbx3 chromodomain binds with comparable affinities to all of the methylated H3K9, H1K26 and G9aK185 peptides. PMID: 22514736
    19. HIV-1 Vpr displaces heterochromatin protein 1-alpha and heterochromatin protein 1-gamma from chromatin, resulting in premature chromatid separation. PMID: 21875947
    20. we show distinct cell-type- and cancer-stage-associated patterns of key heterochromatin marks: heterochromatic adaptor proteins HP1alpha and HP1gamma, compared with the gammaH2AX marker of endogenously activated DNA damage response. PMID: 20695923
    21. HP1gamma localizes to telomeres in S phase, where it is required to establish/maintain cohesion PMID: 21865325
    22. this study reveals that human NIPBL is a novel protein recruited to DSB sites, and the recruitment is controlled by MDC1, RNF168 and HP1gamma. PMID: 21784059
    23. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
    24. HP1 gamma binds CD44 pre-mRNA inside the variant region of CD44. PMID: 21358630
    25. Under oxidative conditions, HP1gamma dimerized and held TIF1beta in a chromatin component and inhibited its repression ability. PMID: 20675861
    26. Pax3 represses transcription through a novel mechanism involving competition between corepressor KAP1 and the heterochromatin-binding protein HP1gamma PMID: 16945326
    27. Suv39H1, HP1gamma and histone H3Lys9 trimethylation play a major role in chromatin-mediated repression of integrated HIV-1 gene expression. PMID: 17245432
    28. In non-differentiated cells, transcriptional intermediary factor TIF1beta/heterochromatin protein HP1 interaction occurs only within euchromatin and involves selectively HP1beta and HP1gamma, but not HP1alpha. PMID: 17381543
    29. Overexpression of HP1-GAMMA in wing imaginal discs caused abnormal wings. PMID: 17575412
    30. present an investigation of DNA methylation and histone modification marks across the HNRPA2B1-CBX3 locus in primary peripheral blood mononuclear cells (PBMCs) to characterise the chromatin structure that underlies UCOE activity PMID: 18032920
    31. Heterochromatin protein gamma coordinately regulates CCN2/CTGF transcription by interacting with nuclear MMP3. PMID: 18172013
    32. the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1gamma, RNA polymerase II, matrin 3, and SAF-A sites PMID: 18618731

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  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1553

    OMIM: 604477

    KEGG: hsa:11335

    STRING: 9606.ENSP00000336687

    UniGene: Hs.381189