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FILIP1L Monoclonal Antibody

  • 中文名稱：
    FILIP1L鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA679703A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: FILIP1L antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 102 kDa
      Observed band size: 29, 80, 102, 130 KDa
      Exposure time：5min
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    FILIP1L單克隆抗體（CUSABIO貨號(hào)：CSB-MA679703A0m）是針對(duì)人源FILIP1L蛋白研發(fā)的高特異性科研試劑，適用于探索細(xì)胞骨架動(dòng)態(tài)調(diào)控及腫瘤發(fā)生機(jī)制等領(lǐng)域的研究。FILIP1L（Filamin A相互作用蛋白1樣）作為調(diào)控肌動(dòng)蛋白結(jié)合的關(guān)鍵分子，在細(xì)胞遷移、極性建立及信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中發(fā)揮重要作用，其異常表達(dá)與多種惡性腫瘤的侵襲轉(zhuǎn)移密切相關(guān)。本產(chǎn)品經(jīng)嚴(yán)格驗(yàn)證可同時(shí)滿足ELISA和Western Blot兩種實(shí)驗(yàn)需求，具有優(yōu)異的人源樣本反應(yīng)特異性，能夠精準(zhǔn)識(shí)別內(nèi)源性FILIP1L蛋白的表達(dá)水平。研究人員可借助該抗體在體外模型中解析腫瘤細(xì)胞遷移機(jī)制，或結(jié)合組織樣本分析FILIP1L在癌癥病理進(jìn)程中的調(diào)控網(wǎng)絡(luò)，為開發(fā)靶向細(xì)胞骨架的新型抗腫瘤策略提供可靠工具。該FILIP1L抗體采用穩(wěn)定生產(chǎn)工藝，批次間一致性經(jīng)過(guò)多輪驗(yàn)證，確保在蛋白印跡和酶聯(lián)免疫實(shí)驗(yàn)中呈現(xiàn)清晰的檢測(cè)信號(hào)，是研究細(xì)胞運(yùn)動(dòng)性、腫瘤微環(huán)境及轉(zhuǎn)移機(jī)制的重要試劑選擇。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) FILIP1L Monoclonal Antibody antibody
  • Uniprot No.：
  • 基因名：
    FILIP1L
  • 別名：
    130 kDa GPBP-interacting protein antibody; 90 kDa GPBP-interacting protein antibody; COL4A3BPIP antibody; DOC-1 antibody; DOC1 antibody; Downregulated in ovarian cancer 1 81 kDa isoform antibody; FIL1L_HUMAN antibody; Filamin A-interacting protein 1-like antibody; FILIP1L antibody; GIP130 antibody; GIP130a antibody; GIP130b antibody; GIP130c antibody; GIP90 antibody; GPBP interacting protein 90 antibody; Protein down-regulated in ovarian cancer 1 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Filamin A-interacting protein 1-like protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal Antibody
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%, Protein G purified
  • 克隆號(hào)：
    4H7G5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
  • 基因功能參考文獻(xiàn)：
    1. FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. PMID: 27750216
    2. Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival. PMID: 27776341
    3. these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis PMID: 24327474
    4. down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers. PMID: 24340050
    5. these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy. PMID: 21693594
    6. a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system. PMID: 21784850
    7. DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells PMID: 15935955

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  • 亞細(xì)胞定位：
    Cytoplasm. Membrane. Nucleus.
  • 蛋白家族：
    FILIP1 family
  • 組織特異性：
    Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. D
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24589

    OMIM: 612993

    KEGG: hsa:11259

    STRING: 9606.ENSP00000346560

    UniGene: Hs.104672