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HAO1 Monoclonal Antibody

  • 中文名稱：
    HAO1鼠單克隆抗體
  • 貨號：
    CSB-MA080172
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Monoclonal Antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    HAO1 Monoclonal Antibody（CUSABIO貨號：CSB-MA080172）是針對羥基酸氧化酶1（HAO1）研發(fā)的高特異性科研抗體，適用于小鼠和大鼠樣本的ELISA及Western Blot檢測。該抗體采用全長人源重組蛋白作為免疫原制備，具有明確的靶向性，可精準(zhǔn)識別HAO1蛋白在代謝通路中的表達(dá)變化。HAO1是過氧化物酶體關(guān)鍵酶，參與脂肪酸α氧化及電子傳遞過程，對研究肝臟代謝、能量穩(wěn)態(tài)及遺傳性代謝疾病機制具有重要科研價值。產(chǎn)品經(jīng)嚴(yán)格驗證，可穩(wěn)定應(yīng)用于細(xì)胞裂解液或組織提取物中目標(biāo)蛋白的定性及半定量分析，為探索脂質(zhì)代謝調(diào)控、氧化應(yīng)激反應(yīng)等基礎(chǔ)研究提供可靠工具。本產(chǎn)品適用于生物醫(yī)學(xué)領(lǐng)域?qū)嶒炇业姆肿訖C制研究、疾病模型構(gòu)建及藥物靶點篩選等場景，不涉及臨床應(yīng)用。儲存時建議分裝后置于-20℃環(huán)境以保持長期活性，避免反復(fù)凍融。
  • Uniprot No.：
  • 基因名：
    HAO1
  • 別名：
    (S) 2 hydroxy acid oxidase antibody; Glycolate oxidase antibody; GOX antibody; GOX1 antibody; HAO1 antibody; HAOX1 antibody; HAOX1_HUMAN antibody; Hydroxyacid oxidase 1 antibody; MGC142225 antibody; MGC142227 antibody; OTTHUMP00000030231 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    10D9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
  • 基因功能參考文獻(xiàn)：
    1. The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase. PMID: 21141873
    2. The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues. PMID: 20054120
    3. These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme. PMID: 17669354
    4. Active site and loop 4 movements within human glycolate oxidase. PMID: 18215067
  • 亞細(xì)胞定位：
    Peroxisome.
  • 蛋白家族：
    FMN-dependent alpha-hydroxy acid dehydrogenase family
  • 組織特異性：
    Liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4809

    OMIM: 605023

    KEGG: hsa:54363

    STRING: 9606.ENSP00000368066

    UniGene: Hs.193640