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KIF7 Monoclonal Antibody

  • 中文名稱：
    KIF7鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA000220
  • 規(guī)格：
    ￥1090
  • 圖片：
    • IHC staining of Mouse Kidney tissue, diluted at 1:200.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號(hào)：CSB-MA000220 KIF7單克隆抗體是一款針對(duì)Hedgehog信號(hào)通路關(guān)鍵調(diào)控因子KIF7蛋白的高特異性科研試劑，適用于人、小鼠、大鼠等多物種研究。KIF7作為纖毛運(yùn)動(dòng)相關(guān)驅(qū)動(dòng)蛋白，在胚胎發(fā)育調(diào)控、細(xì)胞極性建立及腫瘤發(fā)生等生命過程中發(fā)揮重要作用，其異常表達(dá)與多種發(fā)育障礙及腫瘤疾病密切相關(guān)。本產(chǎn)品采用高純度重組蛋白免疫制備，經(jīng)嚴(yán)格質(zhì)控驗(yàn)證其特異性識(shí)別天然及變性狀態(tài)下的KIF7抗原表位，在ELISA和免疫組化（IHC）實(shí)驗(yàn)中展現(xiàn)優(yōu)異性能?？寺√?hào)為4C7的鼠源單抗經(jīng)Protein G純化工藝處理，純度達(dá)95%以上，提供1mg/mL濃度規(guī)格，建議-20℃長(zhǎng)期保存并避免反復(fù)凍融。該抗體特別適用于腫瘤微環(huán)境研究、發(fā)育生物學(xué)機(jī)制探索、信號(hào)通路交互作用分析等基礎(chǔ)科研領(lǐng)域，為揭示KIF7在神經(jīng)管發(fā)育、骨骼形成及腫瘤轉(zhuǎn)移中的分子機(jī)制提供可靠工具。關(guān)鍵詞：KIF7單克隆抗體、Hedgehog信號(hào)通路、纖毛運(yùn)動(dòng)蛋白、腫瘤機(jī)制研究、科研抗體。
  • Uniprot No.：
  • 基因名：
  • 別名：
    EQYK340 antibody; kif7 antibody; KIF7_HUMAN antibody; kinesin family member 7 antibody; kinesin like protein KIF7 antibody; Kinesin-like protein kif7 antibody; UNQ340 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H, M, R
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號(hào)：
    14B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development.
  • 基因功能參考文獻(xiàn)：
    1. two children who both had two missense mutations in the Kinesin Family Member 7 (KIF7) gene, are reported. PMID: 26174511
    2. Kif7 may contribute to pathogenesis of gestational trophoblastic disease through enhancing survival and promoting dissemination of trophoblasts. PMID: 25265279
    3. We identified a Turkish family who had a novel homozygous sequence change, c.2593-2A>C, located at the acceptor splice site of intron 12 of KIF7 (IVS12-2A>C). PMID: 25714560
    4. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. PMID: 25492966
    5. Studied the ExoS to identify unknown cellular targets associated with ExoS-induced cytotoxicity in a P. aeruginosa infection model.A pull-down assay revealed that ExoS bound the truncated KIF7 gene encoding the N-terminal domain (residues 1-109) of KIF7. PMID: 24462444
    6. six novel mutations were identified at the KIF7 locus in five suspected Acrocallosal syndrome cases PMID: 23125460
    7. This study confirms that KIF7 mutations can cause acrocallosal syndrome. PMID: 23142271
    8. report the first missense homozygous disease-causing mutation in KIF7 and expand the clinical spectrum associated with mutations in this gene to include multiple epiphyseal dysplasia PMID: 22587682
    9. The high-resolution structure of the human KIF7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. PMID: 22281744
    10. Data report mutations in the KIF7 gene, a known regulator of sonic hedgehog signaling and a putative ciliary motor protein, in Joubert syndrome patients. PMID: 21633164
    11. Our data show the role of KIF7 in human primary cilia, especially in the Hedgehog pathway through the regulation of GLI targets, and expand the clinical spectrum of ciliopathies. PMID: 21552264

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  • 相關(guān)疾?。?/div>
    Bardet-Biedl syndrome (BBS); Hydrolethalus syndrome 2 (HLS2); Acrocallosal syndrome (ACLS); Joubert syndrome 12 (JBTS12); Al-Gazali-Bakalinova syndrome (AGBK)
  • 亞細(xì)胞定位：
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the cilium tip.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF27 subfamily
  • 組織特異性：
    Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30497

    OMIM: 200990

    KEGG: hsa:374654

    STRING: 9606.ENSP00000377934

    UniGene: Hs.513134