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  4. KRT13 Monoclonal Antibody

KRT13 Monoclonal Antibody

  • 中文名稱：
    KRT13鼠單克隆抗體
  • 貨號：
    CSB-MA299720
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-MA299720 diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-MA299720 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    KRT13單克隆抗體（CUSABIO貨號：CSB-MA299720）是針對人源角蛋白13（KRT13）研發(fā)的高特異性科研試劑，適用于酶聯(lián)免疫吸附實驗（ELISA）及免疫組化（IHC）分析。作為角蛋白家族成員，KRT13在黏膜上皮細胞中特異性表達，參與維持細胞骨架結構完整性和細胞分化調(diào)控，其異常表達與口腔鱗狀細胞癌、食管黏膜病變等疾病密切相關。本產(chǎn)品采用雜交瘤技術制備，經(jīng)嚴格驗證顯示對人源樣本具有優(yōu)異反應性，能夠精準識別天然構象的KRT13蛋白，為研究上皮細胞分化機制、黏膜屏障功能調(diào)控及腫瘤發(fā)生發(fā)展提供可靠工具。在基礎研究領域，該抗體可應用于口腔/食管黏膜組織切片染色、體外培養(yǎng)上皮細胞模型的蛋白表達檢測等實驗，助力研究人員探索KRT13在組織穩(wěn)態(tài)維持與病理狀態(tài)中的分子作用。作為專業(yè)科研試劑，本產(chǎn)品具有高批間穩(wěn)定性和重復性，適用于分子生物學實驗室開展上皮生物學、腫瘤微環(huán)境等領域的前沿研究。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) KRT13 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    47 kDa cytokeratin antibody; CK-13 antibody; CK13 antibody; Cytokeratin 13 antibody; Cytokeratin-13 antibody; K13 antibody; K1C13_HUMAN antibody; Ka13 antibody; Keratin 13 antibody; Keratin antibody; keratin type I cytoskeletal 13 antibody; Keratin-13 antibody; Krt-1.13 antibody; Krt1-13 antibody; KRT13 antibody; MGC161462 antibody; MGC3781 antibody; type I cytoskeletal 13 antibody; Type I keratin Ka13 antibody; WSN2 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from human Cytokeratin 13
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG1, Kappa
  • 純化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆號：
    6H9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. Oral white sponge nevus may manifest variable clinical features. The novel mutation found in the KRT13 gene is believed to add evidence for a mutational hotspot in the mucosal keratins PMID: 29476668
    2. this study reports that KRT13 plays a directive role in prostate cancer bone, brain, and soft tissue metastases PMID: 27835867
    3. Keratin 13 gene is epigenetically suppressed during TGFB1-induced epithelial-mesenchymal transition in a human keratinocyte cell line. PMID: 29326042
    4. Four rare missense variants were identified (ACTBL2 rs73757391 (5q11.2), BTD rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66). PMID: 27378695
    5. KRT13 expression is associated with poor prognosis at multiple stages of disease progression PMID: 27711225
    6. Loss of CK13 expression is associated with invasive oral squamous cell carcinoma. PMID: 26225699
    7. Low KRT13 mRNA expression is associated with oral squamous cell carcinoma. PMID: 25735388
    8. Decreased KRT13 was associated with Esophageal Squamous Cell Carcinoma. PMID: 25851906
    9. Our data provide mechanistic insights into the epigenetic silencing of KRT13 genes in OSCC cells and might be useful for the development of diagnostic markers and novel therapeutic approaches against OSCCs. PMID: 25527207
    10. keratin14 expression can be used to detect early epithelial dysplasia, and that keratin13 and keratin17 expression are useful for detecting neoplastic changes PMID: 24471966
    11. Immunoexpression of CK13 and CK17 in light green-stained superficial cells was associated with more severe morphological atypia in tongue squamous cell carcinoma PMID: 24247036
    12. Fluorescent keratin 13 integrates into the endogenous keratin cytoskeleton in human vulva carcinoma-derived A431 cells, thereby serving as a reliable marker of keratin dynamics. PMID: 23757496
    13. Loss of K13 in oral carcinoma in situ is partly due to its gene repression, but may also be due to some unknown post-translational events. PMID: 22301701
    14. Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19. PMID: 21738394
    15. CK13 expression is elevated in KB cells treated with all-trans retinoic acid or arsenic trioxide. PMID: 19489262
    16. exhibits a regular expression pattern in luminal epithelial cells of secretory phase human endometrium PMID: 11906920
    17. Metaplastic squamous cells differentiate with a decrease of CK18 and an increase of CK13 expression. PMID: 16836912
    18. CK13 positive staining occurs in cervical squamous tumors and in mucinous cervical type adenocarcinomas, while there was no positive staining in non-neoplastic cervical glandular elements PMID: 16949723
    19. The different ligand regulations of KRT13 are due to ligand-differential recruitment of ER and coactivators. PMID: 18951949

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  • 相關疾病：
    White sponge nevus 2 (WSN2)
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6415

    OMIM: 148065

    KEGG: hsa:3860

    STRING: 9606.ENSP00000246635

    UniGene: Hs.654550