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LALBA Monoclonal Antibody

  • 中文名稱(chēng)：
    LALBA鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA000242
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Human Milk, 2) Milk, diluted at 1:3000.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號(hào)：CSB-MA000242 LALBA單克隆抗體是針對(duì)α-乳白蛋白（LALBA）靶點(diǎn)研發(fā)的高特異性科研試劑，該靶點(diǎn)作為乳糖合成酶復(fù)合體的重要組分，在乳腺上皮細(xì)胞中特異性表達(dá)并參與乳糖生物合成調(diào)控，其表達(dá)水平與乳腺功能及乳腺癌相關(guān)機(jī)制研究密切相關(guān)。本產(chǎn)品采用雜交瘤技術(shù)制備，具有優(yōu)異的人源特異性識(shí)別能力，經(jīng)嚴(yán)格驗(yàn)證可穩(wěn)定應(yīng)用于酶聯(lián)免疫吸附試驗(yàn)（ELISA）和蛋白質(zhì)印跡（WB）兩大主流檢測(cè)平臺(tái)，為研究者提供可靠的實(shí)驗(yàn)數(shù)據(jù)支持。該抗體適用于乳腺生物學(xué)研究、乳制品營(yíng)養(yǎng)成分分析、乳腺癌發(fā)生發(fā)展機(jī)制探索等科研領(lǐng)域，尤其適合用于乳腺上皮細(xì)胞功能研究、乳糖代謝通路解析及腫瘤標(biāo)志物篩選等實(shí)驗(yàn)場(chǎng)景。作為經(jīng)過(guò)多批次質(zhì)控驗(yàn)證的科研級(jí)抗體，CUSABIO貨號(hào)：CSB-MA000242在實(shí)驗(yàn)中展現(xiàn)良好的批次穩(wěn)定性和抗原結(jié)合活性，是開(kāi)展LALBA蛋白功能研究、疾病分子機(jī)制探索的重要工具。
  • Uniprot No.：
  • 基因名：
    LALBA
  • 別名：
    a-LACTA antibody; alfaLA antibody; Alpha-lactalbumin antibody; Lactalbumin alpha antibody; Lactose synthase B protein antibody; LALBA antibody; LALBA_HUMAN antibody; Lysozyme-like protein 7 antibody; LYZL7 antibody; MGC138521 antibody; MGC138523 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號(hào)：
    21A10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
  • 基因功能參考文獻(xiàn)：
    1. Studies indicate that alpha-lactalbumin has two domains, a large alpha-helical domain and a small beta-sheet domain connected by a calcium binding loop. PMID: 27238572
    2. High molecular mass complexes are formed with alpha-lactalbumin and alphaB-crystallin, preventing the amorphous aggregation of alpha-lactalbumin. PMID: 23005341
    3. analysis of macromolecular crowding on the structural stability of human alpha-lactalbumin PMID: 22735492
    4. Data show that alpha-lactalbumin and CD14 form a complex in the gut which alters degradation of CD14, suggesting a mechanism by which this key LPS receptor may remain functional in the neonatal gut. PMID: 20717070
    5. The complexes formed by partially folded alpha-lactalbumin with oleic acid display selective apoptotic activity against tumor cells. PMID: 19968717
    6. comparison of the structural and stability properties of the isolated alpha-helical domain of lysozyme with that of alpha-lactalbumin PMID: 11718563
    7. pH-dependent stability of the alpha-lactalbumin molten globule state. PMID: 12833543
    8. Structural characterisation of the human alpha-lactalbumin molten globule at high temperature PMID: 12860137
    9. a functional Ca(2+)-binding site is not required for conversion of alpha-lactalbumin to the active complex or to cause cell death PMID: 14627739
    10. lipids are tissue-specific cofactors in alpha-lactalbumin protein folding PMID: 14627740
    11. NMR study of the conformation of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid. PMID: 15075403
    12. The electrostatic nature of the alpha-lactalbumin (LA)-histone interaction justifies use of alpha-LA as a basis for design of antitumor agents, acting through disorganization of chromatin structure due to interaction between alpha-LA and histone. PMID: 15134431
    13. a folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis PMID: 15141307
    14. the non-cooperative denaturation of the molten globule, alpha-lactalbumin secondary structure elements are stabilized by non-specific, non-native interactions PMID: 15558602
    15. Fold and topology of alpha-lactalbumin may be formed from degenerate groups of side chains. PMID: 15956205
    16. Local interactions as well as hydrophobic interactions formed in the molten globule state play an important role in organizing the structure in the transition state and in guiding the subsequent folding of alpha-lactalbumin. PMID: 16121399
    17. Results describe the reaction mechanism and formation of CIDNP (chemically induced dynamic nuclear polarization) in the photoreactions of the dye 2,2'-dipyridyl with non-native states of bovine and human alpha-lactalbumins in aqueous solution. PMID: 16851644
    18. alpha-lactalbumin molten globule has even more native-like character than suggested by studies conducted at higher temperature PMID: 18939797
    19. recombinant human alpha-LA was purified from transgenic milk and displayed physicochemical properties similar to its natural counterpart with respect to molecular weight, structure, and regulatory activity for beta-1,4-galactosyltransferase PMID: 19038921
    20. the structural preferences of the alpha-LA molten globule at pH 7 at the level of individual residues were investigated. PMID: 19766656
    21. hydrogen exchange behavior of variants using mass spectrometry PMID: 11518539

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 22 family
  • 組織特異性：
    Mammary gland specific. Secreted in milk.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6480

    OMIM: 149750

    KEGG: hsa:3906

    STRING: 9606.ENSP00000301046

    UniGene: Hs.72938