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MB Monoclonal Antibody

  • 中文名稱:
    MB鼠單克隆抗體
  • 貨號(hào):
    CSB-MA079101A0m
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Western Blot
      All lanes: Mouse anti-Human Myoglobin monoclonal antibody at 0.3µg/ml
      Lane 1: Mouse heart muscle lysate
      Lane 2: Recombinant Myoglobin at 10µg
      Secondary HRP labeled Goat polyclonal to Mouse IgG at 1/3000 dilution
      Predicted band size: 18 kDa
      Observed band size: 20 kDa
      Additional bands at: 120 kDa
    • Western Blot
      All lanes: Mouse anti-Human Myoglobin monoclonal antibody at 1µg/ml
      Lane 1: Myoglobin transfected 293 cell lysate
      Secondary HRP labeled Goat polyclonal to Mouse IgG at 1/3000 dilution
      Predicted band size: 18 kDa
      Observed band size: 20 kDa
      Additional bands at: 23, 25, 40 kDa
    • Immunohistochemical of paraffin-embedded human heart tissue using CSB-MA079101A0m at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-MA079101A0m at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse skeletal muscle tissue
      All lanes: MB antibody at 1:2000
      Secondary
      Goat polyclonal to Mouse IgG at 1/50000 dilution
      Predicted band size: 18 kDa
      Observed band size: 18 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    CUSABIO貨號(hào):CSB-MA079101A0m MB單克隆抗體是針對肌紅蛋白(Myoglobin)靶點(diǎn)研發(fā)的高特異性科研試劑,適用于人類和小鼠樣本的多場景檢測需求。該抗體基于成熟雜交瘤技術(shù)制備,可精準(zhǔn)識(shí)別MB蛋白在心肌和骨骼肌組織中的特異性表達(dá),其靶向表位設(shè)計(jì)有效避免了與血紅蛋白等相似結(jié)構(gòu)的交叉反應(yīng),為肌肉損傷相關(guān)研究提供可靠工具。在實(shí)驗(yàn)驗(yàn)證中,該產(chǎn)品經(jīng)嚴(yán)格質(zhì)控確認(rèn)適用于ELISA、Western Blot、免疫組化(IHC)及免疫熒光(IF)四大核心檢測平臺(tái),特別在心肌梗死模型、運(yùn)動(dòng)醫(yī)學(xué)研究等場景中展現(xiàn)出優(yōu)異的檢測靈敏度??蒲腥藛T可將其用于肌肉組織病理分析、細(xì)胞缺氧應(yīng)激研究以及運(yùn)動(dòng)損傷生物標(biāo)志物檢測等基礎(chǔ)研究領(lǐng)域。產(chǎn)品采用即用型凍干粉劑型,配套提供完整免疫原序列及蛋白分子量驗(yàn)證報(bào)告,確保實(shí)驗(yàn)數(shù)據(jù)的可重復(fù)性。作為肌肉相關(guān)疾病機(jī)制研究的關(guān)鍵試劑,該MB單克隆抗體為心血管疾病模型構(gòu)建、肌肉再生研究等前沿課題提供了高效解決方案,滿足分子生物學(xué)實(shí)驗(yàn)室對穩(wěn)定免疫試劑的嚴(yán)苛要求。
  • 產(chǎn)品名稱:
    Mouse anti-Homo sapiens (Human) MB Monoclonal antibody
  • Uniprot No.:
  • 基因名:
    MB
  • 別名:
    MB antibody; MGC13548 antibody; MYG_HUMAN antibody; Myoglobin antibody
  • 宿主:
    Mouse
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Myoglobin protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    IgG1
  • 純化方式:
    >95%, Protein G purified
  • 克隆號(hào):
    7A3D2
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:500
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
  • 基因功能參考文獻(xiàn):
    1. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of Cardiac biomarkers . Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. PMID: 29857573
    2. Report morphology of myoglobin casts in renal biopsies with acute kidney injury. PMID: 27038680
    3. Myoglobin is associated with larger hematoma volume and growth after adjusting potential confounding factors in intracerebral hemorrhage. PMID: 27056440
    4. we found that the A79G polymorphism of the MB gene plays an important role in influencing the development of exercise-induced skeletal muscle damage. PMID: 27323063
    5. Electroanalysis of myoglobin as a marker of acute myocardial infarction by means of screenprinted electrodes modified with multiwalled carbon nanotubes and polymeric artificial antibodies is developed. Plastic antibodies to myoglobin (molecularly imprinted polymers, MIPs) based on o-phenylenediamine were produced by electropolymerization. Molecular imprinting technology in biosensor analysis was used. PMID: 27417724
    6. In the absence of Mb, the Y-shape structure remains intact. So, a weak electrochemical signal is observed. Upon addition of target, the DApt leave the CS and bind to Mb, leading to disassembly of Y-shape structure and following the addition of Exo I, a strong electrochemical signal could be recorded. PMID: 26894983
    7. analysis of myoglobin gene regulatory networks in breast and prostate cancer PMID: 26559958
    8. Data show that with the myoglobin (MYO) monoclonal antibody of high specificity and affinity, a one-step sandwich ELISA for detecting MYO has been established successfully, which provides a basis for the development of domestic ELISA kit. PMID: 26271987
    9. Misfolding and amyloid aggregation of apomyoglobin. PMID: 23839096
    10. A non-ischemic serum myoglobin release is rare, but could be associated in subgroups of patients. PMID: 25002394
    11. Data show that chimeric neuroglobin and myoglobin were generated by swapping a regulatory segment. PMID: 25452214
    12. Findings indicate that myoglobin (Mb) and neuroglobin (Ngb) can be expressed in nonmuscle and non-neural contexts. PMID: 24446190
    13. Analogous to breast cancer, MB expression in prostate cancer is associated with steroid hormone signaling and markers of hypoxia PMID: 25172328
    14. the novel cancer-associated MB splice variants exhibited increased expression in tumor cells subjected to experimental hypoxia; the novel gene regulatory mechanisms unveiled in this study support the idea of a non-canonical role of MB during carcinogenesis PMID: 24026678
    15. Blood myoglobin could serve as a valuable early predictor and marker of rhabdomyolysis and acute myoglobinuric kidney injury PMID: 23931877
    16. High myoglobin expression is associated with renal cell carcinoma. PMID: 24076247
    17. Our LFIA performance was additionally compared with electrochemiluminescence immunoassay (ECLI) detection for simultaneous determination of hs-cTnI and myoglobin in patients with suggestive of acute myocardial infarction . PMID: 23247055
    18. Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7. PMID: 23297402
    19. MD simulations supported NMR results indicating interesting structural/dynamical differences in the average volume and occurrence of the main cavities lining Mb prosthetic group. PMID: 21782983
    20. The mitochondrion-impairing role of MB in hypoxic cancer cells is part of a novel tumor-suppressive function. PMID: 21930697
    21. overexpression in non-small cell lung cancer is associated with histological subtype and hypoxia PMID: 21601304
    22. may have potential significance in the prognostication of lung adenocarcinomas PMID: 21640426
    23. Apomyoglobin mutants with point mutations at val10 forms amyloid structures at permissive temperature. PMID: 21639835
    24. These results show that glutathione reduces hydrogen peroxide-induced protein decomposition due to reduction of the C110-thiyl radical in WTwild type human Mb by electron transfer. PMID: 21256983
    25. Water entry into the heme pockets of isolated hemoglobin subunits was detected by optical methods. PMID: 20668762
    26. Kinetics of interaction between apomyoglobin and phospholipid membrane PMID: 20873231
    27. Using a cardiovascular model suggest that myoglobin oxygen storage/transport becomes significant during systolic reduction of coronary blood flow rather than during diastole. PMID: 20124401
    28. 71% of tumours displayed Mb protein expression in significant correlation with a positive hormone receptor status and better prognosis. PMID: 20531416
    29. The Dimension Vista cTnI, CK-MB, MYO, NTproBNP, and hsCRP methods demonstrate acceptable performance characteristics for use as an aid in the diagnosis and risk assessment of patients presenting with suspected acute coronary syndromes. PMID: 19523464
    30. Screening of exon 2 of the myoglobin gene in high altitude Tibetans does not show novel polymorphism or selection for specific myoglobin alleles as a function of altitude of residence or hypoxic challenge. PMID: 12006163
    31. myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. PMID: 12745799
    32. It was concluded that myoglobin levels on admission and TnT at 2 h had the greatest diagnostic rate for myocardial infarction. PMID: 12760310
    33. Oxidative stress associated with myoglobin expression specifically in mitochondrial diseases. PMID: 14506721
    34. determination of myoglobin concentration and succinate dehydrogenase activity in serial sections indicate that myoglobin can lead to a substantial reduction (18-60%) of the extracellular oxygen tension required to prevent an anoxic core in muscle cells PMID: 15048578
    35. Quantitative test is useful for early diagnosis of acute myocardial infarct and as an indicator of its severity. PMID: 15226628
    36. Binding to blood fatty acid binding protein and may be a marker for cardiac damage in hemodialysis patients. PMID: 15226631
    37. heme rotates about the alpha-gamma axis of human myoglobin without leaving the protein cage PMID: 15485667
    38. energy analysis of myoglobin recognition of oxygen PMID: 15601759
    39. S-nitroso oxymyoglobin stores vasoactive nitric oxide PMID: 15644316
    40. iron mobilization and myoglobin down-modulation are elicited by enhanced erythropoiesis from elevated iron PMID: 17311997
    41. Data show plasma MG may be considered as a novel marker of muscle mass indicating best the mass of MG-rich type 1 and 2a fibers as well as VO(2)max as an important functional readout. PMID: 17605115
    42. analysis of covalent modification, unfolding, and aggregation of human holo-myoglobin induced by tyrosinase-generated quinones PMID: 17883274
    43. In this study, we showed for the first time the connection of ROR2 in Dupuytren's disease. ROR2 and myoglobin may play an important role in the pathophysiology of this disease PMID: 17996904
    44. Hypoxia reprograms calcium signaling and regulates myoglobin expression. PMID: 19005161
    45. myoglobin is expressed at high levels by human carcinoma cells PMID: 19541931
    46. Exposure of vascular smooth muscle (either in cell culture or intact vessels) to pathological nitric oxide (*NO) promotes an up-regulation of the Mb gene and protein, suggesting a feedback relationship between *NO and Mb. PMID: 19650765

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  • 蛋白家族:
    Globin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6915

    OMIM: 160000

    KEGG: hsa:4151

    STRING: 9606.ENSP00000352835

    UniGene: Hs.517586