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MYCBP Monoclonal Antibody

  • 中文名稱：
    MYCBP鼠單克隆抗體
  • 貨號：
    CSB-MA8587101A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunohistochemical of paraffin-embedded Human testis tissue using CSB-MA8587101A0m at dilution of 1:200.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MYCBP單克隆抗體（CUSABIO貨號：CSB-MA8587101A0m）是針對MYC結(jié)合蛋白（MYCBP）研發(fā)的高特異性科研試劑，該靶點(diǎn)作為MYC原癌基因的關(guān)鍵互作蛋白，在細(xì)胞周期調(diào)控、DNA損傷修復(fù)及腫瘤發(fā)生機(jī)制中具有重要研究價(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)ELISA與免疫組化（IHC）雙平臺驗(yàn)證，可精準(zhǔn)識別人類來源的MYCBP抗原表位，適用于腫瘤生物學(xué)、分子病理學(xué)等領(lǐng)域的蛋白質(zhì)相互作用研究?？蒲腥藛T可將其應(yīng)用于腫瘤組織切片中MYCBP蛋白的定位分析、體外培養(yǎng)細(xì)胞模型的蛋白表達(dá)水平檢測，以及基于ELISA平臺的定量分析實(shí)驗(yàn)。產(chǎn)品經(jīng)過嚴(yán)格的質(zhì)控流程，為探索MYC信號通路在腫瘤微環(huán)境調(diào)控、耐藥機(jī)制等前沿課題提供可靠工具。該抗體已成功應(yīng)用于乳腺癌、結(jié)直腸癌等實(shí)體瘤研究的文獻(xiàn)報(bào)道中，是癌癥標(biāo)志物篩選和分子機(jī)理研究的優(yōu)選試劑。
  • 產(chǎn)品名稱：
    mouse anti-Homo sapiens (Human) MYCBP monoclonal antibody
  • Uniprot No.：
  • 基因名：
    MYCBP
  • 別名：
    AMY 1 antibody; AMY-1 antibody; AMY1 antibody; Associate of Myc 1 antibody; C myc binding protein antibody; C-Myc-binding protein antibody; Cmyc binding protein antibody; MYCBP antibody; MYCBP_HUMAN antibody
  • 宿主：
    mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MYCBP Protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    monoclonal
  • 純化方式：
    >95%,protein G purifed
  • 克隆號：
    1D5D5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
  • 基因功能參考文獻(xiàn)：
    1. c-Myc expression is reduced in pterygium compared with normal conjunctiva. PMID: 22050566
    2. Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway. PMID: 20544396
    3. miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities. PMID: 20562918
    4. identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm PMID: 12223483
    5. interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits enzyme acdtivity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex PMID: 12414807
    6. AMY-1 coordinates ADP-Ribosylation Factors-mediated membrane trafficking and signaling pathways. PMID: 16866877
    7. An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration. PMID: 17595061
    8. AMY-1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggest that AMY-1 plays a role in spermatogenesis PMID: 11483602

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
  • 蛋白家族：
    AMY1 family
  • 組織特異性：
    Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7554

    OMIM: 606535

    KEGG: hsa:26292

    STRING: 9606.ENSP00000380702

    UniGene: Hs.591506