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NFKBIB Monoclonal Antibody

  • 中文名稱：
    NFKBIB鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA191867
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using IκB β(mAb diluted at 1:200.
    • Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using IκB βMouse mAb diluted at 1:200.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號(hào)：CSB-MA191867 NFKBIB單克隆抗體是針對(duì)核因子κB抑制蛋白β（NFKBIB/IKBβ）研發(fā)的高特異性科研試劑，適用于人、小鼠、大鼠物種的ELISA和免疫組化（IHC）檢測(cè)。該抗體基于重組蛋白免疫原制備，可特異性識(shí)別NFKBIB蛋白的56-145氨基酸區(qū)域，其作為NF-κB信號(hào)通路關(guān)鍵調(diào)控因子，通過抑制NF-κB核轉(zhuǎn)位參與炎癥反應(yīng)、免疫應(yīng)答及細(xì)胞增殖等重要生物學(xué)過程研究。產(chǎn)品經(jīng)過嚴(yán)格驗(yàn)證，在ELISA實(shí)驗(yàn)中展現(xiàn)高靈敏度的抗原結(jié)合能力，適用于體外定量檢測(cè)；IHC應(yīng)用則支持石蠟或冰凍組織切片中目標(biāo)蛋白的定位分析，為探究NF-κB通路在腫瘤、自身免疫疾病及感染性疾病中的分子機(jī)制提供可靠工具。本產(chǎn)品滿足炎癥機(jī)制研究、信號(hào)轉(zhuǎn)導(dǎo)分析及基因表達(dá)調(diào)控等科研需求，是探索轉(zhuǎn)錄因子動(dòng)態(tài)平衡和細(xì)胞應(yīng)激反應(yīng)的重要試劑。關(guān)鍵詞：NFKBIB單抗、IKBβ檢測(cè)試劑、ELISA抗體、免疫組化試劑、NF-κB通路研究。
  • Uniprot No.：
  • 基因名：
  • 別名：
    I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆號(hào)：
    5C3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
  • 基因功能參考文獻(xiàn)：
    1. The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
    2. data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
    3. our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
    4. NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
    5. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
    6. VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
    7. data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
    8. None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
    9. increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    NF-kappa-B inhibitor family
  • 組織特異性：
    Expressed in all tissues examined.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7798

    OMIM: 604495

    KEGG: hsa:4793

    STRING: 9606.ENSP00000312988

    UniGene: Hs.9731