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PGC Monoclonal Antibody

  • 中文名稱：
    PGC鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA112991A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunohistochemical of paraffin-embedded human gastric cancer tissue using CSB-MA112991A0m at dilution of 1:200
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PGC單克隆抗體（CUSABIO貨號(hào)：CSB-MA112991A0m）是針對(duì)胃蛋白酶原C（Pepsinogen C）的科研用免疫試劑，該靶標(biāo)蛋白作為胃部消化酶前體在胃黏膜功能研究中具有重要價(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)特異性驗(yàn)證可識(shí)別人源PGC蛋白表位，適用于酶聯(lián)免疫吸附（ELISA）和免疫組化（IHC）兩大實(shí)驗(yàn)平臺(tái)。其種屬特異性經(jīng)過嚴(yán)格驗(yàn)證，確保對(duì)人源樣本檢測(cè)的可靠性，能夠有效支持胃蛋白酶原代謝調(diào)控、胃黏膜細(xì)胞分化等基礎(chǔ)研究，為消化系統(tǒng)疾病機(jī)制探索提供高質(zhì)量的抗體工具。該抗體在胃功能相關(guān)蛋白組學(xué)分析、病理切片標(biāo)記等科研場(chǎng)景中展現(xiàn)優(yōu)異性能，是開展胃蛋白酶原家族研究的關(guān)鍵試劑。
  • 產(chǎn)品名稱：
    mouse anti-Homo sapiens (Human) PGC monoclonal antibody
  • Uniprot No.：
  • 基因名：
    PGC
  • 別名：
    Gastricsin antibody; PEPC antibody; PEPC_HUMAN antibody; pepsin C antibody; Pepsinogen C antibody; pepsinogen group II antibody; PGC antibody; PGII antibody; preprogastricsin antibody; Progastricsin antibody
  • 宿主：
    mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PGC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    monoclonal
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%,protein G purifed
  • 克隆號(hào)：
    1G1H3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hydrolyzes a variety of proteins.
  • 基因功能參考文獻(xiàn)：
    1. Recombinant pepsin C and pepsinogen C were purified from transgenic rice culture medium, and the NH2-terminal 5-residue sequences were verified by amino acid sequencing. PMID: 29108629
    2. serum levels correlated with age, sex and the level of Helicobacter pylori infection PMID: 27865295
    3. Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. PMID: 26486507
    4. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer. PMID: 25857852
    5. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis. PMID: 26158864
    6. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17] PMID: 22066020
    7. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer. PMID: 25551587
    8. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication. PMID: 25028655
    9. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions. PMID: 24895149
    10. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer. PMID: 24586594
    11. plasma PG II level significantly correlated with H. pylori-infected gastric cancer PMID: 23326145
    12. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis. PMID: 24009139
    13. Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux. PMID: 23311720
    14. PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to atrophic gastritis and/or gastric cancer. PMID: 23455381
    15. Data suggest that serum pepsinogen I/II ratio (pepsinogen A/C ratio) is correlated with diabetic nephropathy and thus may be a biological marker for degree of urinary albumin excretion in patients with type 2 diabetes. PMID: 23047493
    16. The serum levels of PG II and G-17 were significantly higher in Changle than those in Fuan. PMID: 23117263
    17. Data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms. PMID: 23178618
    18. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured. PMID: 22066020
    19. Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies. PMID: 21303408
    20. PGC gene insertion/deletion polymorphism is negatively related to PGC protein expression in gastric mucosa, but is not related to the serum PGC level. PMID: 19624876
    21. Pepsinogen C insertion/deletion polymorphism and Helicobacter pylori infection seem to present a positive interaction in the development of gastric cancer. PMID: 19173902
    22. Pepsinogen C is expressed in a quarter of ovarian carcinomas and might identify a subset of patients with different prognosis PMID: 12128264
    23. These results suggest that there is some relation between pepsinogen C gene polymorphism and gastric cancer, and the person with homogenous allele 1 predisposes to gastric cancer more than those with other genotypes. PMID: 12508350
    24. results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach PMID: 12698190
    25. human cathelicidin antimicrobial peptide-18 in seminal plasma is processed to generate a 38-amino acid antimicrobial peptide ALL-38 by the prostate-derived protease gastricsin when incubated at a pH corresponding to the vaginal pH PMID: 12759353
    26. Pepsinogen C can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer. PMID: 15200883
    27. pepsinogen C may be expressed by uveal melanoma and suggest that this protein could be considered as a new, unfavorable prognostic factor in these tumors PMID: 15503827
    28. Higher levels of Pepsinogen II is associated with early gastric cancer PMID: 15688378
    29. pepsinogen C genetic variants have a role in gastric cancer PMID: 16937501
    30. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. PMID: 17559360
    31. pepsinogen C has a role in SP-B proteolytic processing in alveolar type 2 cells PMID: 18256027
    32. role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients PMID: 18447628
    33. pepsinogens may have a role in esophageal squamous dysplasia PMID: 18844222
    34. The pepsinogen C gene polymorphism increases an individual's susceptibility to gastric cancer and its precancerous conditions PMID: 19132389
    35. Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the stomach corpus. PMID: 19731026

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase A1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8890

    OMIM: 169740

    KEGG: hsa:5225

    STRING: 9606.ENSP00000362116

    UniGene: Hs.1867