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  4. STK38L Monoclonal Antibody

STK38L Monoclonal Antibody

  • 中文名稱：
    STK38L鼠單克隆抗體
  • 貨號：
    CSB-MA896491A0m
  • 規(guī)格：
    ￥1,200
  • 圖片：
    • Western Blot
      Positive WB detected in: SKT38L antibody at 1:1000
      Lane 1: HepG2 whole cell lysate
      Lane 2: 293T whole cell lysate tissue
      Lane 3: Jurkat whole cell lysate
      Lane 4: Raw264.7 whole cell lysate
      Lane 5: K562 whole cell lysate
      Secondary
      Goat polyclonal to Mouse IgG at 1/20000 dilution
      Predicted band size: 55, 44 KDa
      Observed band size: 55 KDa
      Exposure time: 5min
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號：CSB-MA896491A0m STK38L單克隆抗體是針對絲氨酸/蘇氨酸蛋白激酶38L（STK38L）研發(fā)的高特異性科研試劑，該靶點屬于STE20蛋白激酶家族成員，在細胞周期調(diào)控、DNA損傷應答及細胞凋亡等關鍵生物學過程中發(fā)揮重要作用。本產(chǎn)品采用雜交瘤技術制備，經(jīng)嚴格驗證具有優(yōu)異的人源特異性，適用于Western Blot和ELISA兩種主流檢測平臺，可精準識別內(nèi)源性STK38L蛋白。在基礎研究領域，該抗體廣泛應用于探究STK38L在腫瘤發(fā)生發(fā)展、神經(jīng)退行性疾病及免疫調(diào)控中的分子機制，特別適用于信號通路解析、蛋白質(zhì)相互作用研究以及疾病模型中的靶點表達水平檢測。通過優(yōu)化的抗原表位設計和穩(wěn)定的批間一致性，該抗體可為蛋白質(zhì)印跡實驗提供清晰的條帶分辨效果，并在酶聯(lián)免疫實驗中展現(xiàn)高靈敏度的檢測性能，是探索STK38L功能研究的理想工具?？蒲腥藛T可通過該產(chǎn)品深入解析STK38L在細胞應激反應、代謝調(diào)控中的分子網(wǎng)絡，為相關疾病機制研究提供可靠的技術支持。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) STK38L Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    STK38L
  • 別名：
    KIAA0965 antibody; NDR2 antibody; NDR2 protein kinase antibody; nuclear Dbf2 related 2 antibody; Nuclear Dbf2 related kinase 2 antibody; Nuclear Dbf2-related kinase 2 antibody; Serine/threonine protein kinase 38 like antibody; Serine/threonine-protein kinase 38-like antibody; ST38L_HUMAN antibody; Stk38l antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase 38-like protein (212-464AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%, Protein G purified
  • 克隆號：
    7B12B3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the regulation of structural processes in differentiating and mature neuronal cells.
  • 基因功能參考文獻：
    1. It was found that STK38L*I/D genotype had positive association with longevity in the ethnically homogeneous group of Tatars from the Republic of Bashkortostan, Russia. PMID: 28556638
    2. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15. PMID: 23435566
    3. Activation of NDR2 is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3, autophosphorylation of Ser281/2, and binding of MOB1A. PMID: 16314523
    4. NDR2 is an upstream kinase of ARK5 that plays an essential role in tumor progression through ARK5 PMID: 16488889
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitously expressed with highest levels observed in the thymus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17848

    OMIM: 615836

    KEGG: hsa:23012

    STRING: 9606.ENSP00000373684

    UniGene: Hs.184523