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Sdc1 Monoclonal Antibody

Rare Species
  • 中文名稱：
    Sdc1鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA0208881A0m
  • 規(guī)格：
    ￥1320
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    Sdc1單克隆抗體（CUSABIO貨號(hào)：CSB-MA0208881A0m）是針對Syndecan-1（CD138）跨膜蛋白開發(fā)的科研級(jí)試劑，該靶點(diǎn)在細(xì)胞信號(hào)傳導(dǎo)、粘附調(diào)控及細(xì)胞外基質(zhì)相互作用中發(fā)揮重要功能，尤其在腫瘤微環(huán)境調(diào)控、上皮細(xì)胞分化等領(lǐng)域具有研究價(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，宿主來源為小鼠，經(jīng)嚴(yán)格質(zhì)控驗(yàn)證其在大鼠種屬中表現(xiàn)出優(yōu)異反應(yīng)性，適用于ELISA檢測體系。該抗體具有高特異性識(shí)別能力，可精準(zhǔn)檢測Sdc1蛋白的表達(dá)水平，為研究腫瘤發(fā)生機(jī)制、細(xì)胞間通訊網(wǎng)絡(luò)及組織微環(huán)境動(dòng)態(tài)變化提供可靠工具。應(yīng)用場景涵蓋體外腫瘤細(xì)胞模型分析、信號(hào)通路蛋白互作研究以及特定病理狀態(tài)下Sdc1表達(dá)譜的定量檢測，適用于分子生物學(xué)、細(xì)胞生物學(xué)等基礎(chǔ)研究領(lǐng)域。本產(chǎn)品嚴(yán)格按照科研抗體標(biāo)準(zhǔn)生產(chǎn)，確保實(shí)驗(yàn)結(jié)果的穩(wěn)定性和重復(fù)性，是探索Sdc1在細(xì)胞增殖、遷移及微環(huán)境調(diào)控中分子機(jī)制的理想選擇，為癌癥研究、再生醫(yī)學(xué)等前沿領(lǐng)域提供高質(zhì)量的檢測支持。
  • 產(chǎn)品名稱：
    mouse anti-Rattus norvegicus (Rat) Sdc1 monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Sdc1 antibody; Synd1 antibody; Syndecan-1 antibody; SYND1 antibody; CD antigen CD138 antibody
  • 宿主：
    mouse
  • 反應(yīng)種屬：
    Rat
  • 免疫原：
    Recombinant Rat Syndecan-1 protein
  • 免疫原種屬：
    Rattus norvegicus (Rat)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    monoclonal
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%,protein G purifed
  • 克隆號(hào)：
    1B4F4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
  • 基因功能參考文獻(xiàn)：
    1. Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids. PMID: 27037369
    2. down-regulation of Syndecan-1 could inhibit VEGF-VEGFR-2 signaling through regulating internalization of VEGFR-2. PMID: 27075925
    3. expression upregulated two months after renal transplantation PMID: 25972509
    4. data suggest that after renal transplantation loss of hepatic HS together with increased syndecan-1 shedding hampers lipoprotein binding and uptake by the liver contributing to dyslipidemia PMID: 25154787
    5. analysis of the molecular events that drive endocytosis of syndecan-1, a raft-dependent receptor and identification of its novel endocytic motif, MKKK PMID: 23525115
    6. The abnormal expression of HSPG may be an important molecular mechanism that leads to the occurrence and development of proteinuria in adriamycin-induced nephropathy rats. PMID: 20506637
    7. role in regulatory mechanism of apoptosis PMID: 11979781
    8. Syndecan-1 mRNA expression is not modulated by FSH as it would result from the antagonistic effects of increased intracellular cAMP and intracellular calcium levels. PMID: 12135485
    9. The major injury-related change, seen in injured brain and cultured glia, was an increase in 2-O-sulphated HS and increased syndecan-1, suggesting novel approaches to modulating scar formation. PMID: 18279312

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 數(shù)據(jù)庫鏈接：