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  4. TUBB Monoclonal Antibody

TUBB Monoclonal Antibody

  • 中文名稱：
    TUBB鼠單克隆抗體
  • 貨號：
    CSB-MA080255
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號：CSB-MA080255 TUBB單克隆抗體是針對微管蛋白β亞基研發(fā)的高特異性科研工具，該靶標(biāo)作為真核生物細(xì)胞骨架核心組分，在維持細(xì)胞形態(tài)、胞內(nèi)物質(zhì)運輸及有絲分裂過程中發(fā)揮關(guān)鍵作用。本產(chǎn)品采用合成肽段GAGNNWAKGHYTEGA-KLH復(fù)合物免疫小鼠制備，屬IgG2b亞型，可特異性識別人、大鼠、小鼠等11個物種的TUBB蛋白，經(jīng)嚴(yán)格驗證適用于ELISA、Western Blot和免疫組化實驗體系。該抗體在-20°C或-80°C條件下長期穩(wěn)定保存，為研究微管動態(tài)組裝、細(xì)胞周期調(diào)控以及神經(jīng)軸突運輸機制提供可靠工具，廣泛應(yīng)用于細(xì)胞生物學(xué)、腫瘤微環(huán)境研究和神經(jīng)退行性疾病模型構(gòu)建等基礎(chǔ)科研領(lǐng)域，助力科研人員深入探索細(xì)胞結(jié)構(gòu)與功能調(diào)控網(wǎng)絡(luò)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Beta 4 tubulin antibody; Beta 5 tubulin antibody; beta Ib tubulin antibody; Beta1 tubulin antibody; Class I beta tubulin antibody; M40 antibody; MGC117247 antibody; MGC16435 antibody; OK/SW cl.56 antibody; OK/SWcl.56 antibody; TBB5_HUMAN antibody; TUBB 1 antibody; TUBB 2 antibody; TUBB 5 antibody; TUBB antibody; TUBB1 antibody; TUBB2 antibody; TUBB5 antibody; tubulin beta 1 chain antibody; Tubulin beta 2 chain antibody; tubulin beta 5 chain antibody; Tubulin beta chain antibody; Tubulin beta class I antibody; tubulin beta polypeptide antibody; Tubulin beta-5 chain antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    H,R,M,Mk,Dg,C,Hm,Rb,Sh,Insect,Yeast
  • 免疫原：
    Recombinant Protein
  • 免疫原種屬：
    H, R, M, Mk, Dg, C, Hm, Rb, Sh, Insect, Yeast
  • 標(biāo)記方式：
    HRP
  • 抗體亞型：
    IgG
  • 克隆號：
    10F9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻：
    1. human tumor cells can acquire spontaneous mutations in beta1-tubulin that cause resistance to paclitaxel PMID: 20103599
    2. Roles of tubulin beta 1,3 residues Ala428 and Thr429 in microtubule formation in vivo. PMID: 19074767
    3. TUBB exon 4 mutations and mismatch repair defects do not play a significant role in paclitaxel/cisplatin resistance PMID: 16095531
    4. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. PMID: 26637975
    5. the dipole moments of each tubulin isotype may influence their functional characteristics within the cell, resulting in differences for MT assembly kinetics and stability PMID: 16941085
    6. Leucine point mutations viz. L215H, L217R, and L225M were reported for paclitaxel resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations in TUBB1 was explored using molecular docking, molecular dynamics simulation, binding energy estimation, free energy decomposition, principle component analysis and free energy landscape methods. PMID: 27233604
    7. Data suggest a looser binding of the ligand in tubulin mutants. PMID: 26081685
    8. Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability. PMID: 26165356
    9. Data suggest that, while lacking a stable structure, NFL-TBS.40-63 peptide (a peptide derived from light neurofilament protein) preferentially binds on a specific single site located near C-terminal end of beta-tubulin. PMID: 26016807
    10. Citrullination of TUBB is associated with neoplasms. PMID: 24099319
    11. mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells. PMID: 24161989
    12. Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer. PMID: 23818224
    13. results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 in embryonic neurogenesis and microcephaly PMID: 23246003
    14. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
    15. Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H), but it was associated with immunomodulatory treatment failure. PMID: 23157319
    16. Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer. PMID: 21327297
    17. This is the first cell-based evidence to support a beta-tubulin-binding site for peloruside A and laulimalide. PMID: 21653684
    18. Mutational analysis of the class I beta-tubulin gene in human breast cancer PMID: 12209587
    19. the influence of beta-tubulin mutations in paclitaxel resistance in advanced non-small cell lung cancer PMID: 12826311
    20. Review of studies comparing beta-tubulin mutations with antitubulin drug resistance. Throws doubts on earlier such correlation because of the existence of many pseudogenes for beta-tubulin. PMID: 15003198
    21. These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis. PMID: 16371510
    22. cDNA subtraction revealed increased expression of alpha3-tubulin in the taxol-resistant cell line. PMID: 16380805
    23. Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. PMID: 17569113
    24. Results suggest that glutamate198 in beta-tubulin is a critical determinant for microtubule stability and Taxol resistance. PMID: 17869412
    25. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

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  • 相關(guān)疾病：
    Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6); Skin creases, congenital symmetric circumferential, 1 (CSCSC1)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20778

    OMIM: 156610

    KEGG: hsa:203068

    STRING: 9606.ENSP00000339001

    UniGene: Hs.636480