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ACSF3 Antibody

  • 中文名稱：
    ACSF3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA674579LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA674579LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA674579LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ACSF3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ACSF3
  • 別名：
    ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，ACSF3 Antibody (CSB-PA674579LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ACSF3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA674579LB01HU ACSF3 Antibody, HRP conjugated ELISA
    FITC CSB-PA674579LC01HU ACSF3 Antibody, FITC conjugated
    Biotin CSB-PA674579LD01HU ACSF3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
  • 基因功能參考文獻(xiàn)：
    1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism PMID: 28479296
    2. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease. PMID: 23337955
    3. data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma. PMID: 22420028
    4. ACSF3 is a candidate gene for non-classical CMAMMA observed in our patients. PMID: 21785126
    5. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. PMID: 21846720
    6. mutations in ACSF3, encoding a putative methylmalonyl-CoA and malonyl-CoA synthetase, were identified as a cause of combined malonic and methylmalonic aciduria. PMID: 21841779

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  • 相關(guān)疾?。?/div>
    Combined malonic and methylmalonic aciduria (CMAMMA)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 27288

    OMIM: 614245

    KEGG: hsa:197322

    STRING: 9606.ENSP00000320646

    UniGene: Hs.461727