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ADAMTS15 Antibody

  • 中文名稱：
    ADAMTS15兔多克隆抗體
  • 貨號：
    CSB-PA837445LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA837445LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ADAMTS15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ADAMTS15
  • 別名：
    A disintegrin and metalloproteinase with thrombospondin motifs 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 preproprotein antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein antibody; ADAM metallopeptidase with thrombospondin type 1 motif 15 antibody; ADAM TS 15 antibody; ADAM TS15 antibody; ADAM-TS 15 antibody; ADAM-TS15 antibody; ADAMTS 15 antibody; ADAMTS-15 antibody; ADAMTS15 antibody; ATS15_HUMAN antibody; MGC126403 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 15 protein (801-913AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ADAMTS15 Antibody (CSB-PA837445LA01HU)，的標記方式是Non-conjugated。對于ADAMTS15 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA837445LB01HU ADAMTS15 Antibody, HRP conjugated ELISA
    FITC CSB-PA837445LC01HU ADAMTS15 Antibody, FITC conjugated
    Biotin CSB-PA837445LD01HU ADAMTS15 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
  • 基因功能參考文獻：
    1. ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas. PMID: 28323982
    2. ADAMTS15 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    3. ADAMTS15 is a candidate gene for intracranial aneurysms PMID: 25649796
    4. ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4. PMID: 25099234
    5. Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation. PMID: 23233679
    6. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene PMID: 20590445
    7. ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma PMID: 16152618
    8. ADAMTS15 may be target of inactivating mutations in human cancer. PMID: 19458070

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix. Cell surface.
  • 組織特異性：
    Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16305

    OMIM: 607509

    KEGG: hsa:170689

    STRING: 9606.ENSP00000299164

    UniGene: Hs.534221