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AGGF1 Antibody

  • 中文名稱：
    AGGF1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001444ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001444ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA001444ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AGGF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AGGF 1 antibody; Aggf1 antibody; AGGF1_HUMAN antibody; Angiogenic factor VG5Q antibody; Angiogenic factor with G patch and FHA domains 1 antibody; G patch domain containing protein 7 antibody; G patch domain-containing protein 7 antibody; GPATC 7 antibody; GPATC7 antibody; GPATCH 7 antibody; GPATCH7 antibody; HSU84971 antibody; HUS84971 antibody; hVG5Q antibody; Vasculogenesis gene on 5q antibody; Vasculogenesis gene on 5q protein antibody; VG5Q antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Angiogenic factor with G patch and FHA domains 1 protein (1-70AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
  • 基因功能參考文獻(xiàn)：
    1. Aggf1 has a role in regulating vascular injury. PMID: 28153879
    2. High expression of AGGF1 predicts poor prognosis in gastric cancer patients. PMID: 28289272
    3. AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians. PMID: 27704351
    4. Overexpression of AGGF1 is correlated with angiogenesis in hepatocellular carcinoma. PMID: 25796501
    5. AGGF1 reduces myocardial apoptosis and inflammation and enhances angiogenesis, leading to decreased infarct size after I/R injury. PMID: 24893993
    6. results of this study indicate that hypoxia down-regulates expression of the AGGF1 protein, but not AGGF1 mRNA, by inducing expression of miR-27a PMID: 24462738
    7. AGGF1 potently attenuated TNF-alpha triggered NF-kappaB pathway, as indicated by the decreased promoter activity, nuclear distribution and phosphorylation of NF-kappaB p65 subunit as well as the increased protein level of IkappaBalpha. PMID: 23628701
    8. analysis of sphingolipid modulation of angiogenic factor expression in neuroblastoma PMID: 21576349
    9. results define VG5Q as an angiogenic factor, establish VG5Q as a susceptibility gene for Klippel-Trenaunay syndrome, and show that increased angiogenesis is a molecular pathogenic mechanism of KTS PMID: 14961121
    10. VG5Q, E133K is a mutation that causes Klippel-Trenaunay and other overgrowth syndromes. PMID: 16443853
    11. This review describes the somatic mutation for angiogenic factor VG5Q, which may be the cause of the multisystem disorder Klippel-Trenaunay syndrome. PMID: 16911369
    12. identified two tagSNPs, rs13155212 and rs7704267 that capture information for all common variants in AGGF1 as a candidate susceptibility gene for Klippel-Trenaunay syndrome PMID: 18564129
    13. Knockdown of GATA1 expression by siRNA reduced expression of AGGF1, and resulted in endothelial cell apoptosis and inhibition of vessel formation. PMID: 19556247

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  • 相關(guān)疾?。?/div>
    Klippel-Trenaunay syndrome (KTS)
  • 亞細(xì)胞定位：
    Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.
  • 組織特異性：
    Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24684

    OMIM: 149000

    KEGG: hsa:55109

    STRING: 9606.ENSP00000316109

    UniGene: Hs.634849