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AKAP3 Antibody

  • 中文名稱：
    AKAP3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA588403
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunofluorescence analysis of NIH/3T3 cells, using AKAP3 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AKAP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AKAP3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human AKAP3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
  • 基因功能參考文獻(xiàn)：
    1. AKAP3 correlates with triple negative status and disease free survival in breast cancer. PMID: 26458542
    2. study reports the isolation of AKAP3 and CTp11 Cancer/testis antigens from hepatocellular carcinoma patient sera PMID: 22941507
    3. CABYR variants form a complex not only with the scaffolding protein AKAP3 but also with another RII-like domain-containing protein in the sperm fibrous sheath. PMID: 21240291
    4. evidence of tyrosine phosphorylation during sperm capacitation PMID: 12509440
    5. In Cox multivariate analysis, AKAP3 mRNA expression was found to be a significant predictor of both overall and progression-free survival in patients with poorly differentiated tumors. PMID: 14618620
    6. AKAP-3 demonstrates tumor-restricted expression and appears to be associated with worse overall survival. PMID: 16005946
    7. AKAP3 is a novel target for protein S-nitrosylation in spermatozoa. PMID: 17683036

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  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
  • 蛋白家族：
    AKAP110 family
  • 組織特異性：
    Testis specific; only expressed in spermatids.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 373

    OMIM: 604689

    KEGG: hsa:10566

    STRING: 9606.ENSP00000228850

    UniGene: Hs.98397