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ALX3 Antibody

  • 中文名稱：
    ALX3兔多克隆抗體
  • 貨號：
    CSB-PA000867
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using ALX3 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ALX3
  • 別名：
    ALX3Homeobox protein aristaless-like 3 antibody; Proline-rich transcription factor ALX3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ALX3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional regulator with a possible role in patterning of mesoderm during development.
  • 基因功能參考文獻(xiàn)：
    1. Genome scan using 250k Nsp1 array followed by exome and Sanger sequence analysis revealed a novel homozygous nonsense variant (c.604C>T, p.Gln202*) in the ALX3 gene resulting in frontorhiny in the family. This is the first mutation in the ALX3 gene, underlying frontorhiny, in Pakistani population. PMID: 29215096
    2. Exclusion of mutations in ALX3 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    3. We report a novel Y214X mutation in ALX3 in frontorhiny. PMID: 22106187
    4. The lack of a chromosome 1-derived fragment of ALX3 in restriction landmark genomic scanning and virtual genome scans of neuroblastomas is attributable to hypermethylation. PMID: 11807986
    5. Alx3 participates in the regulation of insulin gene expression in pancreatic beta-cells. PMID: 16825292
    6. ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny. PMID: 19409524
    7. Rat Alx3 undergoes restrictive or permissive interactions with nuclear proteins that determine its binding to and transactivation from TAAT target sites selected in a cell-specific manner. PMID: 15226305
    8. Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin genes. PMID: 16825292

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  • 相關(guān)疾病：
    Frontonasal dysplasia 1 (FND1)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 449

    OMIM: 136760

    KEGG: hsa:257

    STRING: 9606.ENSP00000358807

    UniGene: Hs.669953