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  4. ANKRD2 Antibody, Biotin conjugated

ANKRD2 Antibody, Biotin conjugated

  • 中文名稱：
    ANKRD2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA875635LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ANKRD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ANKRD2
  • 別名：
    ANKRD2 antibody; ARPPAnkyrin repeat domain-containing protein 2 antibody; Skeletal muscle ankyrin repeat protein antibody; hArpp antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ankyrin repeat domain-containing protein 2 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
  • 基因功能參考文獻：
    1. The results set the stage for investigation of the specific functions and interactions of the Ankrd2 isoforms in healthy and diseased human striated muscles. PMID: 27393496
    2. The Ankrd2 was found to be expressed in both the cytoplasm and nucleus, independently from maturation status of cardiomyocytes. PMID: 25585647
    3. Report structure activity relationships for ANKRD2. PMID: 25125175
    4. Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kappaB repressor subunit p50. PMID: 24434510
    5. The orthologs of ANKRD2 in mouse and rat, which are also titin binding proteins, are stretch-response genes associated with slow muscle function and these proteins are part of a separate mechanotransduction system to the one that regulates muscle mass. PMID: 15677738
    6. Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers. PMID: 22185618
    7. Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes PMID: 22016770
    8. Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation PMID: 21737686
    9. These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis. PMID: 12679596
    10. Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation PMID: 15136035
    11. Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma PMID: 16021567
    12. ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma but not in chromophobe renal cell carcinomas. PMID: 17206105

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  • 亞細胞定位：
    Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
  • 組織特異性：
    Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 495

    OMIM: 610734

    KEGG: hsa:26287

    STRING: 9606.ENSP00000306163

    UniGene: Hs.73708