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ANO3 Antibody

  • 中文名稱：
    ANO3兔多克隆抗體
  • 貨號：
    CSB-PA001814GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ANO3
  • 別名：
    ANO3 antibody; C11orf25 antibody; TMEM16C antibody; GENX-3947Anoctamin-3 antibody; Transmembrane protein 16C antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ANO3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. Does not exhibit calcium-activated chloride channel (CaCC) activity.
  • 基因功能參考文獻(xiàn)：
    1. Study reports a novel c.1969G>A mutation in the ANO3 gene in a family presenting with a typical dystonia phenotype consistent with previous reports: onset mainly after the fourth decade, begins as cervical dystonia, but evolves to segmental dystonia, without leg involvement or any generalized dystonia. PMID: 27392807
    2. This study demonstrated that whole-exome sequencing show reveled ANO3 mutation with early-onset generalized dystonia. PMID: 27666935
    3. HTRA2 and ANO3 mutations are not common causes of essential tremor PMID: 27881096
    4. This study demonstrated that Mutations in ANO3 may cause Dystonia. PMID: 25847575
    5. rat Ano3 (also known as Tmem16c) interacts with, and alters the activity of the sodium-activated potassium channel Slack. Reduced expression of Ano3 in rat models results in increased pain sensitivity. PMID: 23872594
    6. ANO3 causes a varied phenotype of young-onset or adult-onset craniocervical dystonia with tremor and/or myoclonic jerks PMID: 24442708
    7. Low frequency missense variants in ANO3 occur in both cases and controls, warranting further assessment of this gene in primary torsion dystonia pathogenesis. PMID: 24151159
    8. Our findings indicate that rare exonic variants in ANO3 do not play a major role in the development of essentail tremor PMID: 24094724
    9. Mutations in ANO3 are a cause of autosomal-dominant craniocervical dystonia. PMID: 23200863
    10. The significant single nucleotide polymorphisms are located within the overlapping anoctamin 3 (ANO3) and mucin 15 (MUC15) genes. PMID: 22657408
    11. C11orf25, FLJ10261 (ORAOV2), C12orf3 and FLJ34272 constitute a family of eight-transmembrane proteins with N- and C-terminal tails facing the cytoplasm. PMID: 12739008

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  • 相關(guān)疾病：
    Dystonia 24 (DYT24)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anoctamin family
  • 組織特異性：
    Highly expressed in the forebrain striatum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14004

    OMIM: 610110

    KEGG: hsa:63982

    STRING: 9606.ENSP00000256737

    UniGene: Hs.577269