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AP3D1 Antibody

  • 中文名稱：
    AP3D1兔多克隆抗體
  • 貨號：
    CSB-PA001876GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    AP3D1
  • 別名：
    Adapter-related protein complex 3 subunit delta-1 antibody; adaptor-related protein complex 3, delta 1 subunit antibody; ADTD antibody; AP 3 complex delta subunit antibody; AP-3 complex subunit delta antibody; AP-3 complex subunit delta-1 antibody; ap3d1 antibody; AP3D1_HUMAN antibody; Delta 1 subunit of adaptor-related protein complex 3 antibody; Delta Adaptin antibody; Delta-adaptin antibody; hBLVR antibody; Subunit of putative vesicle coat adaptor complex AP 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human AP3D1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
  • 基因功能參考文獻(xiàn)：
    1. Unexpectedly, no evidence of binding between the N-terminal matrix (MA) domain of HIV-1 Gag and the cellular Adaptor Protein AP-3 (AP-3delta) was observed in these in vitro experiments. PMID: 22705971
    2. The matrix region of HIV-1 Gag interacts directly with the delta subunit of the AP-3 complex, and that this interaction plays an important functional role in particle assembly PMID: 15766529
    3. AP-3 and AP-1 function in partially redundant pathways to transfer tyrosinase from distinct endosomal subdomains to melanosomes and that the AP-3 pathway ensures that tyrosinase averts entrapment on internal membranes of forming multivesicular bodies PMID: 16162817
    4. The studies demonstrate a role for AP-3 in HIV replication in a tetraspanin-rich compartment in dendritic cells (DC) and contribute to the elucidation of the trafficking pathways required for DC-T cell transfer of HIV-1 infection. PMID: 18034776
  • 相關(guān)疾病：
    Hermansky-Pudlak syndrome 10 (HPS10)
  • 亞細(xì)胞定位：
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Adaptor complexes large subunit family
  • 組織特異性：
    Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 568

    OMIM: 607246

    KEGG: hsa:8943

    STRING: 9606.ENSP00000344055

    UniGene: Hs.512815