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AP4B1 Antibody

  • 中文名稱：
    AP4B1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA897585LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: AP4B1 antibody at 3μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: U251 whole cell lysate
      Lane 3: LO2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 84, 35 kDa
      Observed band size: 84 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897585LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA897585LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AP4B1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AP4B1
  • 別名：
    AP4B1AP-4 complex subunit beta-1 antibody; AP-4 adaptor complex subunit beta antibody; Adaptor-related protein complex 4 subunit beta-1 antibody; Beta subunit of AP-4 antibody; Beta4-adaptin antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，AP4B1 Antibody (CSB-PA897585LA01HU)，的標(biāo)記方式是Non-conjugated。對于AP4B1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA897585LB01HU AP4B1 Antibody, HRP conjugated ELISA
    FITC CSB-PA897585LC01HU AP4B1 Antibody, FITC conjugated
    Biotin CSB-PA897585LD01HU AP4B1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
  • 基因功能參考文獻(xiàn)：
    1. Novel homozygous 2-bp deletion in AP4B1 was found in siblings with intellectual disability and spastic tetraplegia. PMID: 24781758
    2. Data suggest that AP4B1 mutations cause spastic paraplegia type 47 and should be considered in early onset spastic paraplegia with intellectual disability. PMID: 22290197
  • 相關(guān)疾?。?/div>
    Spastic paraplegia 47, autosomal recessive (SPG47)
  • 亞細(xì)胞定位：
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
  • 蛋白家族：
    Adaptor complexes large subunit family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 572

    OMIM: 607245

    KEGG: hsa:10717

    STRING: 9606.ENSP00000256658

    UniGene: Hs.515048