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  4. APOA1BP Antibody

APOA1BP Antibody

  • 中文名稱：
    APOA1BP兔多克隆抗體
  • 貨號：
    CSB-PA000834
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using AI-BP Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NAXE
  • 別名：
    NAXE antibody; AIBP antibody; APOA1BP antibody; YJEFN1 antibody; NAD(P)H-hydrate epimerase antibody; EC 5.1.99.6 antibody; Apolipoprotein A-I-binding protein antibody; AI-BP antibody; NAD(P)HX epimerase antibody; YjeF N-terminal domain-containing protein 1 antibody; YjeF_N1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human AI-BP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
  • 基因功能參考文獻：
    1. NAXE gene mutations are associated with early-onset progressive encephalopathy. PMID: 30022751
    2. Study shows a homozygous mutation in the APOA1BP is associated with a lethal infantile leukoencephalopathy.This is the first report of a defect in the nicotinamide nucleotide repair system in humans. PMID: 27122014
    3. NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood PMID: 27616477
    4. AIBp contributes to mitotic entry and bipolar spindle assembly. PMID: 26114227
    5. AIBP accelerates cholesterol efflux from endothelial cells to HDL and thereby regulates angiogenesis PMID: 23719382
    6. Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver. PMID: 17521614

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  • 相關疾病：
    Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy (PEBEL)
  • 亞細胞定位：
    Mitochondrion. Secreted.
  • 蛋白家族：
    NnrE/AIBP family
  • 組織特異性：
    Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18453

    OMIM: 608862

    KEGG: hsa:128240

    STRING: 9606.ENSP00000357218

    UniGene: Hs.528320