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ARHGEF17 Antibody

  • 中文名稱：
    ARHGEF17兔多克隆抗體
  • 貨號(hào)：
    CSB-PA080066
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ARHGEF17
  • 別名：
    ARHGEF17 antibody; KIAA0337 antibody; TEM4Rho guanine nucleotide exchange factor 17 antibody; 164 kDa Rho-specific guanine-nucleotide exchange factor antibody; p164-RhoGEF antibody; p164RhoGEF antibody; Tumor endothelial marker 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p164-RhoGEF.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
  • 基因功能參考文獻(xiàn)：
    1. data implicate TEM4 as an essential regulator of the actin cytoskeleton that ensures proper membrane protrusion at the leading edge of migrating cells and efficient cellular migration via suppression of actomyosin contractility PMID: 23825001
    2. Interaction of the central domain of ARHGEF17 with Mps1. PMID: 26953350
    3. The rho guanine nucleotide exchange factor 17 is drastically alter the effect of cGMP/cGK involving signaling pathways on RhoA-activated downstream effectors. PMID: 23195829
    4. TEM4 contains a novel actin binding domain and binding to actin is essential for TEM4 subcellular localization and activity. PMID: 22911862
    5. a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart PMID: 12071859
    6. Identification of ARHGEF17, mutations in melanoma. PMID: 18677770

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  • 組織特異性：
    Highly expressed in the heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21726

    KEGG: hsa:9828

    STRING: 9606.ENSP00000263674

    UniGene: Hs.533719