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ART1 Antibody

  • 中文名稱：
    ART1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002155LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA002155LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ART1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ART1GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 antibody; EC 2.4.2.31 antibody; ADP-ribosyltransferase C2 and C3 toxin-like 1 antibody; ARTC1 antibody; Mono(ADP-ribosyl)transferase 1 antibody; CD antigen CD296 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 protein (46-142AA )
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ART1 Antibody (CSB-PA002155LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ART1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA002155LB01HU ART1 Antibody, HRP conjugated ELISA
    FITC CSB-PA002155LC01HU ART1 Antibody, FITC conjugated
    Biotin CSB-PA002155LD01HU ART1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has ADP-ribosyltransferase activity toward GLP1R.
  • 基因功能參考文獻(xiàn)：
    1. Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma. PMID: 27277835
    2. up-regulation of ART1 expression is associated with the aggressiveness of glioma. PMID: 27466078
    3. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway PMID: 26847718
    4. The altered function and expression of P2X7 and ART1 in the human CD39+ Treg or CD39- Treg cells could participate in the resistance against cell death induced by ATP or NAD. PMID: 26307000
    5. This study provides evidence that ARTC1 is activated during the endoplasmic-reticulum stress response, which results in acute ADP-ribosylation of GRP78/BiP paralleling translational inhibition. PMID: 25292337
    6. ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease PMID: 16627471
    7. ADPRT Ala762Val polymorphism may play a role in the etiology of squamous cell carcinoma of the head and neck or in linkage disequilibrium with other untyped protective alleles. PMID: 17614107

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  • 亞細(xì)胞定位：
    Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Arg-specific ADP-ribosyltransferase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 723

    OMIM: 601625

    KEGG: hsa:417

    STRING: 9606.ENSP00000250693

    UniGene: Hs.382188