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ASCC1 Antibody

  • 中文名稱：
    ASCC1兔多克隆抗體
  • 貨號：
    CSB-PA002196LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, Jurkat whole cell lysate, Mouse heart tissue, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue, Mouse stomach tissue
      All lanes: ASCC1 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 42 kDa
      Observed band size: 46 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA002196LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ASCC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASCC1
  • 別名：
    Activating signal cointegrator 1 complex subunit 1 antibody; ASC-1 complex subunit p50 antibody; ASC1 complex subunit p50 antibody; ASC1p50 antibody; ASCC1 antibody; ASCC1_HUMAN antibody; CGI 18 antibody; RP11-150D20.4 antibody; Trip4 complex subunit p50 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Activating signal cointegrator 1 complex subunit 1 protein (1-315AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ASCC1 Antibody (CSB-PA002196LA01HU)，的標(biāo)記方式是Non-conjugated。對于ASCC1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA002196LB01HU ASCC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA002196LC01HU ASCC1 Antibody, FITC conjugated
    Biotin CSB-PA002196LD01HU ASCC1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
  • 基因功能參考文獻(xiàn)：
    1. Our patient was also found to have a homozygous frameshift variant (c.157dupG, p.Glu53Glyfs*19) in ASCC1 , thereby representing the second known case. This confirms ASCC1 involvement in a severe neuromuscular disease lying within the spinal muscular atrophy or primary muscle disease spectra PMID: 28218388
    2. ASCC1 inhibits NF-kappaB activation and a truncated and inactive variant of ASCC1 is associated with a more severe disease, which could have clinical value for assessing the progression and prognosis of Rheumatoid Arthritis. PMID: 26503956
    3. Three major genes, MSR1, ASCC1, and CTHRC1 were associated with Barrett esophagus/esophageal adenocarcinoma PMID: 21791690
    4. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. PMID: 19074642
  • 相關(guān)疾?。?/div>
    Barrett esophagus (BE); Spinal muscular atrophy with congenital bone fractures 2 (SMABF2)
  • 亞細(xì)胞定位：
    Nucleus. Nucleus speckle.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24268

    OMIM: 614215

    KEGG: hsa:51008

    STRING: 9606.ENSP00000339404

    UniGene: Hs.500007