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ASMT Antibody

  • 中文名稱：
    ASMT兔多克隆抗體
  • 貨號：
    CSB-PA002216LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of 293 cells with CSB-PA002216LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ASMT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASMT
  • 別名：
    acetylserotonin methyltransferase (Y chromosome) antibody; acetylserotonin N-methyltransferase antibody; Acetylserotonin O-methyltransferase antibody; ASMT antibody; ASMTY antibody; HIOM_HUMAN antibody; HIOMT antibody; HIOMTY antibody; Hydroxyindole O-methyltransferase antibody; OTTHUMP00000022834 antibody; OTTHUMP00000022835 antibody; OTTHUMP00000022836 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Acetylserotonin O-methyltransferase protein (221-316AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ASMT Antibody (CSB-PA002216LA01HU)，的標記方式是Non-conjugated。對于ASMT Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA002216LB01HU ASMT Antibody, HRP conjugated ELISA
    FITC CSB-PA002216LC01HU ASMT Antibody, FITC conjugated
    Biotin CSB-PA002216LD01HU ASMT Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
  • 基因功能參考文獻：
    1. Even when considering only high-grade glioma patients, a low ASMT:CYP1B1 value, which suggests decreased melatonin and enhanced aggressiveness, was strongly associated with poor survival. Overall, our data reveal the prognostic value of the melatonergic system of gliomas and provide insights into the therapeutic role of melatonin. PMID: 26510398
    2. two single nucleotide polymorphisms (rs4446909 and rs5989681)in the promoter of ASMT do not contribute to the pathogenesis of schizophrenia in Chinese-Han subjects PMID: 26154813
    3. results indicate that expression of sleep onset delay relates to melatonin pathway genes. PMID: 25059483
    4. These data suggest a relationship between decreased mRNA and protein expression levels of ASMT gene and cognitive impairment. PMID: 24881886
    5. Bipolar disorder-associated SNP influences sleep and circadian rhythms in bipolar patients in remission and controls. PMID: 24308489
    6. study presents the X-ray crystal structure of ASMT; analysis of nonsynonymous variants found that the majority of these mutations reduced or abolished ASMT activity; estimate the allelic frequency of ASMT deleterious mutations ranges from 0.66% in Europe to 2.97% in Asia PMID: 22775292
    7. results support the possible involvement of the ASMT gene in autism spectrum disorders PMID: 23995775
    8. ASMT might be a susceptibility gene for autism PMID: 23349736
    9. Rare and common variations in ASMT might play a role in bipolar disorder vulnerability. PMID: 22694957
    10. Data found a splice site mutation in ASMT (IVS5+2T>C) and one stop mutation in MTNR1A (Y170X) - detected exclusively in patients with ADHD - for which biochemical analyses indicated that they abolish the activity of ASMT and MTNR1A. PMID: 21615493
    11. The expression of HIOMT in epithelial cells of striated ducts in human submandibular glands. PMID: 21437622
    12. study of genetic variability of ASMT in a cohort of patients with intellectual disability (ID)and controls; identifed patients with deleterious ASMT mutations and decreased ASMT activity; however, study does not support ASMT as a causative gene for ID PMID: 21251267
    13. Results show the AA genotype and the GG genotype of ASMT were associated with lower risk for having recurrent depressive disorder. In turn, patients with depression were characterised by reduced mRNA expression for ASMT. PMID: 20433639
    14. The results of this study indicated that HIOMT immunohistochemistry may be useful for the diagnosis of PPTs and be a prognostic factor in pineal parenchymal cell tumors. PMID: 20418777
    15. Two polymorphisms located in the acetylserotonin methyltransferase (ASMT)promoter were more frequent in autism spectrum disorders (ASD); analyses revealed a highly significant decrease in ASMT activity and melatonin level in individuals with ASD. PMID: 17505466
    16. The data of this study does not support a correleation between asmt gene and autism. PMID: 17957233

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  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family
  • 組織特異性：
    Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level, and not at the protein level.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 750

    OMIM: 300015

    KEGG: hsa:438

    UniGene: Hs.522572