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ATP6V1H Antibody

  • 中文名稱：
    ATP6V1H兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004431
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using V-ATPase H Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Atp6v1h antibody; ATPase; H+ transporting; lysosomal 50/57kDa; V1 subunit H antibody; CGI 11 antibody; CGI11 antibody; EC 3.6.3.14 antibody; MSTP042 antibody; NBP1 antibody; Nef binding protein 1 antibody; Nef-binding protein 1 antibody; Protein VMA13 homolog antibody; SFD antibody; SFDalpha antibody; SFDbeta antibody; V ATPase subunit H antibody; V-ATPase 50/57 kDa subunits antibody; V-ATPase subunit H antibody; V-type proton ATPase subunit H antibody; Vacuolar ATP synthase subunit H antibody; Vacuolar proton pump subunit H antibody; Vacuolar proton pump subunit SFD antibody; VATH_HUMAN antibody; VMA13 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human V-ATPase H.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
  • 基因功能參考文獻(xiàn)：
    1. These data provide evidence that partial loss of ATP6V1H function results in osteoporosis/osteopenia. PMID: 27924156
    2. These studies have uncovered a new, ATP6V1H-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9/MMP13 could be therapeutic targets for patients with this rare genetic disease. PMID: 28158191
    3. ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity. PMID: 21871445
    4. Our study shows that multiple mechanisms of pump dysfunction result from B1 subunit mutations with a common outcome being defective assembly PMID: 18368028
  • 蛋白家族：
    V-ATPase H subunit family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18303

    OMIM: 608861

    KEGG: hsa:51606

    STRING: 9606.ENSP00000352522

    UniGene: Hs.491737