Adh5 Antibody
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中文名稱:Adh5兔多克隆抗體
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貨號(hào):CSB-PA001357LA01MO
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規(guī)格:¥440
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Mus musculus (Mouse) Adh5 Polyclonal antibody
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Uniprot No.:
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基因名:Adh5
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別名:Adh5 antibody; Adh-2 antibody; Adh2 antibody; Alcohol dehydrogenase class-3 antibody; EC 1.1.1.1 antibody; Alcohol dehydrogenase 2 antibody; Alcohol dehydrogenase 5 antibody; Alcohol dehydrogenase B2 antibody; ADH-B2 antibody; Alcohol dehydrogenase class-III antibody; Glutathione-dependent formaldehyde dehydrogenase antibody; FALDH antibody; FDH antibody; GSH-FDH antibody; EC 1.1.1.- antibody; S-(hydroxymethyl)glutathione dehydrogenase antibody; EC 1.1.1.284 antibody
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宿主:Rabbit
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反應(yīng)種屬:Mouse
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免疫原:Recombinant Mouse Alcohol dehydrogenase class-3 protein (2-374AA)
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免疫原種屬:Mus musculus (Mouse)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,Adh5 Antibody (CSB-PA001357LA01MO),的標(biāo)記方式是Non-conjugated。對(duì)于Adh5 Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB
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推薦稀釋比:
Application Recommended Dilution WB 1:1000-1:5000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.
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基因功能參考文獻(xiàn):
- Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis. PMID: 29860106
- Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy. PMID: 29074597
- Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione. PMID: 26746429
- Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation. PMID: 28883020
- These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes. PMID: 28674030
- GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance. PMID: 27412893
- Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells. PMID: 26178404
- Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage. PMID: 26412304
- S-nitrosoglutathione reductase-dependent modification of PPARgamma alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages. PMID: 25798618
- These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states. PMID: 24684653
- Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2). PMID: 24895131
- GSNOR appears to play a crucial role in controlling pulmonary and systemic infection by K. pneumoniae. PMID: 24239886
- A critical role for GSNOR in maintaining genomic integrity. PMID: 23354311
- This study suggests that S-nitrosoglutathione reductase degradation of S-nitrosoglutathione is a vital step in the expression of ventilatory roll-off PMID: 23183419
- GSNOR deficiency has a role in hepatocarcinogenesis, which is prevented by iNOS inhibition PMID: 23440427
- Increasing the denitrosylation capacity of cardiomyocytes, via cardiomyocyte-specific overexpression of GSNOR, protects against sepsis-induced myocardial depression. PMID: 23417863
- Compared the protein expression profiles in the livers of wild-type and GSNOR-deficient (GSNOR(-/-) ) mice that were challenged with lipopolysaccharide; subsequently id'd 19 upregulated and 19 downregulated proteins in GSNOR(-/-) mice using mass spec. PMID: 22623366
- These results indicate that systemic hemodynamic responses (vascular tone and cardiac contractility), both under basal conditions and after adrenergic activation, are regulated through concerted actions of NO synthase/GSNOR. PMID: 22366318
- protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes PMID: 21385828
- Data show that GSNO-R activity was elevated in lung homogenates from female compared to male mice. PMID: 21103380
- GSNOR denitrosylates connexin 43 at the gap junctions between vascular epithelial and vascular smooth muscle cells. PMID: 21071693
- GSNOR, likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system. PMID: 20980633
- Data suggest that GSNOR deficiency, through dysregulated S-nitrosylation, may promote hepatocellular carcinoma, possibly by inactivating a DNA repair system. PMID: 20371487
- following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs) PMID: 15919956
- Mechanisms are presented through which nitric acid and S-glutathione mediate nitrosative stress, as well as the cellular pathways of protein S-nitrosylation and denitrosylation involving GSNO reductase. PMID: 19138101
- GSNOR inhibitors to be novel tools for regulating nitric oxide bioactivity and assessing the role of SNOs in vivo. PMID: 19596685
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亞細(xì)胞定位:Cytoplasm.
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蛋白家族:Zinc-containing alcohol dehydrogenase family, Class-III subfamily
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組織特異性:Ubiquitous.
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