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Alpha-conotoxin LvIA Antibody

  • 中文名稱：
    Alpha-conotoxin LvIA Antibody
  • 貨號(hào)：
    CSB-PA926267XA01DWC
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Conus lividus (Livid cone) Alpha-conotoxin LvIA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Alpha-conotoxin LvIA
  • 別名：
    Alpha-conotoxin LvIA (Alpha-CTx LvIA) (Fragment)
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Conus lividus (Livid cone)
  • 免疫原：
    Recombinant Conus lividus (Livid cone) Alpha-conotoxin LvIA protein (21-36aa)
  • 免疫原種屬：
    Conus lividus (Livid cone)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 nAChR with high selectivity (IC(50)=8.67 nM (on rat) and 17.5 (on human)). Has also weaker activity on alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=108 nM (on rat)), alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC(50)=121 nM (on rat)), alpha-3-beta-4 (CHRNA3-CHRNB4) (IC(50)=148 nM (on rat)), and alpha-7/CHRNA7 nAChRs (IC(50)=3000 nM (on rat)). When tested on mouse with hot-plate tests, this toxin significantly increases the base pain threshold and shows analgesic effects.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Conotoxin A superfamily
  • 組織特異性：
    Expressed by the venom duct.