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B3GALNT2 Antibody

  • 中文名稱：
    B3GALNT2兔多克隆抗體
  • 貨號：
    CSB-PA002489GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    B3GALNT2
  • 別名：
    3-GalNAc-T2 antibody; 3-N-acetylgalactosaminyltransferase 2 antibody; 3-N-acetylgalactosaminyltransferase II antibody; B3GalNAc T2 antibody; B3GalNAcT2 antibody; b3galnt2 antibody; B3GL2_HUMAN antibody; Beta 1,3 galactosaminyltransferase 2 antibody; Beta 1,3 N acetylgalactosaminyltransferase 2 antibody; Beta 1,3 N acetylgalactosaminyltransferase II antibody; Beta 1,3 N acetylgalactosaminyltransferase II MGC39558 antibody; Beta 3 GalNAc T2 antibody; Beta-1 antibody; beta-1,3-GalNAc-T2 antibody; Beta3GalNAcT2 antibody; MDDGA11 antibody; MGC39558 antibody; UDP GalNAc:betaGlcNAc beta 1,3 galactosaminyltransferase polypeptide 2 antibody; UDP-GalNAc:beta-1 antibody; UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human B3GALNT2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
  • 基因功能參考文獻：
    1. Mutations in B3GALNT2 give rise to a novel muscular dystrophy-dystroglycanopathies syndrome presentation, characterized by intellectual disability and seizure, but without any apparent muscular involvement. PMID: 29273094
    2. B3GALNT2 is a gene associated with congenital muscular dystrophy with brain malformations. PMID: 24084573
    3. B3GALNT2 overexpression is associated with breast cancer. PMID: 24285400
    4. Results demonstrate a role for B3GALNT2 in the glycosylation of alpha-DG and show that B3GALNT2 mutations can cause dystroglycanopathy with muscle and brain involvement. PMID: 23453667
    5. Although the GalNAcbeta1-3GlcNAcbeta1-R structure has not been reported in humans or other mammals, we have discovered a novel human glycosyltransferase producing this structure on N- and O-glycans. PMID: 14724282

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  • 相關(guān)疾病：
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum.
  • 蛋白家族：
    Glycosyltransferase 31 family
  • 組織特異性：
    Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28596

    OMIM: 610194

    KEGG: hsa:148789

    STRING: 9606.ENSP00000355559

    UniGene: Hs.498143