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  4. BATF3 Antibody, FITC conjugated

BATF3 Antibody, FITC conjugated

  • 中文名稱：
    BATF3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA882082LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BATF3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BATF3 antibody; SNFTBasic leucine zipper transcriptional factor ATF-like 3 antibody; B-ATF-3 antibody; 21 kDa small nuclear factor isolated from T-cells antibody; Jun dimerization protein p21SNFT antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Basic leucine zipper transcriptional factor ATF-like 3 protein (2-65AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
  • 基因功能參考文獻：
    1. The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
    2. Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. PMID: 28708849
    3. Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. PMID: 26034174
    4. correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions PMID: 12087103
    5. overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% PMID: 15467742

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28915

    OMIM: 612470

    KEGG: hsa:55509

    STRING: 9606.ENSP00000243440

    UniGene: Hs.62919