BCL7B Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q9BQE9
基因名：

BCL7B
別名：

B cell CLL/lymphoma 7 protein family member B antibody; B cell CLL/lymphoma 7B antibody; B-cell CLL/lymphoma 7 protein family member B antibody; BCL 7B antibody; BCL7B antibody; BCL7B_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human BCL7B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression.
基因功能參考文獻(xiàn)：
1. We herewith propose that the BCL7B gene, located in the chromosomal region commonly deleted in Williams syndrome, could potentially have a role in this particular association. PMID: 27771473
2. our data indicate that BCL7B/BCL-7 has some roles in maintaining the structure of nuclei and is involved in the modulation of multiple pathways, including Wnt and apoptosis. PMID: 25569233
3. BCL7B gene deltion is associated with Williams-Beuren Syndrome leading to Burkitt Leukemia. PMID: 23018576
相關(guān)疾病：

BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
蛋白家族：

BCL7 family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 1005

OMIM: 605846

KEGG: hsa:9275

STRING: 9606.ENSP00000223368

UniGene: Hs.647051