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  4. BTBD10 Antibody

BTBD10 Antibody

  • 中文名稱：
    BTBD10兔多克隆抗體
  • 貨號：
    CSB-PA002841GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    BTBD10
  • 別名：
    BTBD10 antibody; GMRP1BTB/POZ domain-containing protein 10 antibody; Glucose metabolism-related protein 1 antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human BTBD10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
  • 基因功能參考文獻：
    1. findings suggest that reduced BTBD10 expression is closely linked to the pathogenesis of sporadic amyotrophic lateral sclerosis PMID: 23320755
    2. Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo. PMID: 22388351
    3. GMRP1 regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway. PMID: 21267538
    4. BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation. PMID: 18160256
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21445

    OMIM: 615933

    KEGG: hsa:84280

    STRING: 9606.ENSP00000278174

    UniGene: Hs.332382