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CA5A Antibody

  • 中文名稱：
    CA5A兔多克隆抗體
  • 貨號：
    CSB-PA056143
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from A549 cells, LOVO cells and K562 cells, using CA5A antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CA5A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CA5A
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CA5A.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Reversible hydration of carbon dioxide. Low activity.
  • 基因功能參考文獻：
    1. In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B. Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect PMID: 26913920
    2. CA5A alterations cause hyperammonemia in early childhood that result in mitochondrial carbonic anhydrase VA deficiency PMID: 24530203
    3. activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II. PMID: 17174092
  • 相關(guān)疾病：
    Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1377

    OMIM: 114761

    KEGG: hsa:763

    STRING: 9606.ENSP00000309649

    UniGene: Hs.177446